Hydrogen Sulfide

Hydrogen Sulfide

SCHEMBL29100291

FC(F)(F)c1cccc2sc3ccccc3c12.S

nearest known ligand 0.48

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GPR3 P46089 1/20 0.48
SLC9A1 P19634 2/20 0.41
KIF11 P52732 1/20 0.41
MAPT P10636 5/20 0.38
MEN1 O00255 3/20 0.38
KMT2A Q03164 3/20 0.38
POLB P06746 2/20 0.38
DUSP3 P51452 1/20 0.38
BLM P54132 1/20 0.38
PTPN5 P54829 1/20 0.38
PTPN11 Q06124 1/20 0.38
MCL1 Q07820 1/20 0.38
CTDSP1 Q9GZU7 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
IDO1 P14902 1/20 0.38
HPGD P15428 4/20 0.36
SMN1; SMN2 Q16637 3/20 0.36
ALDH1A1 P00352 3/20 0.36
RAB9A P51151 2/20 0.36
KDM4E B2RXH2 3/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6489524 0.98 GPR3 (0.50) GPR3SLC9A1KIF11MAPTMEN1
SCHEMBL28076011 0.93 GPR3 (0.45) GPR3SLC9A1KIF11MAPTMEN1
SCHEMBL5527348 0.86 MAPT (0.47) GPR3SLC9A1KIF11MAPTMEN1
Trifluoromethanesulfonic Acid SCHEMBL29631864 0.85 SLC9A1 (0.44) GPR3SLC9A1KIF11MAPTMEN1
Hydrochloric Acid SCHEMBL28289368 0.84 MAPT (0.46) GPR3SLC9A1KIF11MAPTMEN1
SCHEMBL28075901 0.80 GPR3 (0.43) GPR3SLC9A1KIF11MAPTMEN1
SCHEMBL27541383 0.80 GPR3 (0.52) GPR3MAPTMEN1KMT2APOLB
SCHEMBL27558709 0.78 GPR3 (0.50) GPR3MAPTMEN1KMT2APOLB
SCHEMBL2388003 0.78 GPR3 (0.56) GPR3KIF11MAPTMEN1KMT2A
SCHEMBL28980148 0.78 GPR3 (0.41) GPR3SLC9A1MAPTMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116924867-A Method for synthesizing trifluoromethyl substituted aromatic hydrocarbon compound 郑州泰基鸿诺医药股份有限公司 2023-10-24 CN disclosed