Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GSK3A | P49840 | 2/20 | 0.33 |
| ▸ | GSK3B | P49841 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | PTAFR | P25105 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.33 |
| ▸ | PRKCG | P05129 | 1/20 | 0.33 |
| ▸ | PRKACA | P17612 | 1/20 | 0.33 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | MARK3 | P27448 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.33 |
| ▸ | AKT2 | P31751 | 1/20 | 0.33 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.33 |
| ▸ | PRKX | P51817 | 1/20 | 0.33 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2911586 | 1.00 | MAPT (0.34) | MAPTPOLBKDM4EGSK3AGSK3B | |
| SCHEMBL2912533 | 0.92 | GSK3B (0.34) | MAPTPOLBGSK3AGSK3BLMNA | |
| SCHEMBL2909788 | 0.92 | GSK3B (0.34) | MAPTPOLBGSK3AGSK3BLMNA | |
| SCHEMBL2913577 | 0.91 | AHR (0.37) | GSK3AGSK3BALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL2911914 | 0.91 | AHR (0.37) | GSK3AGSK3BALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL2904127 | 0.91 | MET (0.35) | GSK3AGSK3BLMNAMAPK1ALDH1A1 | |
| SCHEMBL2911532 | 0.91 | ALDH1A1 (0.41) | MAPTPOLBGSK3AGSK3BLMNA | |
| SCHEMBL2904664 | 0.91 | CYP1A2 (0.34) | MAPTPOLBGSK3AGSK3BLMNA | |
| SCHEMBL2911193 | 0.91 | MET (0.35) | GSK3AGSK3BLMNAMAPK1ALDH1A1 | |
| SCHEMBL2911906 | 0.91 | CYP1A2 (0.34) | MAPTPOLBGSK3AGSK3BLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537099-B1 | PYRROLE BASED INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | NOVARTIS VACCINES & DIAGNOSTIC (US) | 2010-08-11 | — | — | EP | disclosed |