Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CCR1 | P32246 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | FPR2 | P25090 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | RNF114 | Q9Y508 | 1/20 | 0.36 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.36 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.35 |
| ▸ | TRPC6 | Q9Y210 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29104056 | 1.00 | MAPT (0.40) | MAPTNPSR1CCR1AKR1C3ALDH1A1 | |
| SCHEMBL29104082 | 0.85 | AKR1C3 (0.41) | MAPTNPSR1AKR1C3ALDH1A1GAA | |
| SCHEMBL29104036 | 0.81 | DRD2 (0.43) | MAPTNPSR1CCR1AKR1C3ALDH1A1 | |
| SCHEMBL29104034 | 0.81 | DRD2 (0.43) | MAPTNPSR1CCR1AKR1C3ALDH1A1 | |
| SCHEMBL29104088 | 0.78 | NR1H2 (0.51) | MAPTALDH1A1LMNA | |
| SCHEMBL29104051 | 0.78 | NR1H2 (0.51) | MAPTALDH1A1LMNA | |
| SCHEMBL29104020 | 0.78 | NR1H2 (0.51) | MAPTALDH1A1LMNA | |
| SCHEMBL28094591 | 0.73 | AKR1C3 (0.40) | MAPTNPSR1AKR1C3ALDH1A1GAA | |
| SCHEMBL29104074 | 0.73 | MAPT (0.38) | MAPTNPSR1AKR1C3ALDH1A1GAA | |
| SCHEMBL29104070 | 0.73 | MAPT (0.38) | MAPTNPSR1AKR1C3ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117003755-A | Pyrazolopyridazinone derivatives, compositions and uses thereof | 北京伯汇生物技术有限公司 | 2023-11-07 | — | — | CN | disclosed |