Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | HTR1D | P28221 | 1/20 | 0.37 |
| ▸ | HTR1B | P28222 | 1/20 | 0.37 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.37 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.37 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14007417 | 0.81 | KDM4E (0.50) | TMEM97SIGMAR1LOXL2KDM4ECYP3A4 | |
| SCHEMBL12474 | 0.80 | PYCR1 (0.50) | LTA4HTSHRBRAFKDM4ESMN1; SMN2 | |
| SCHEMBL3044715 | 0.79 | TSHR (0.45) | LTA4HTSHRBRAFSIGMAR1SMN1; SMN2 | |
| SCHEMBL16549287 | 0.79 | MEN1 (0.52) | LTA4HTSHRTMEM97SIGMAR1KDM4E | |
| SCHEMBL1239426 | 0.79 | KDM4E (0.59) | LTA4HTSHRBRAFTMEM97SIGMAR1 | |
| SCHEMBL3151763 | 0.79 | LTA4H (0.47) | LTA4HTSHRBRAFSIGMAR1KDM4E | |
| SCHEMBL615516 | 0.78 | TSHR (0.65) | LTA4HTSHRSIGMAR1SMN1; SMN2MAOB | |
| SCHEMBL26012094 | 0.76 | LTA4H (0.45) | LTA4HTSHRBRAFSMN1; SMN2F10 | |
| SCHEMBL12449593 | 0.76 | SIGMAR1 (0.47) | LTA4HTSHRBRAFTMEM97SIGMAR1 | |
| SCHEMBL23560372 | 0.75 | KDM4E (0.39) | TMEM97SIGMAR1LOXL2KDM4ECYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4288438-A1 | DERIVATIVES OF IMIDAZO[4,5-D]PYRIDAZINE, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION | Sanofi (FR) | 2023-12-13 | — | — | EP | disclosed |
| CN-117098761-A | Imidazo [4,5-d ] pyridazine derivatives, preparation thereof and therapeutic use thereof | 赛诺菲 | 2023-11-21 | — | — | CN | disclosed |
| WO-2022167438-A1 | DERIVATIVES OF IMIDAZO[4,5-d]PYRIDAZINE, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION | SANOFI (FR) | 2022-08-11 | — | — | WO | disclosed |