Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 11/20 | 0.43 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 5/20 | 0.42 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.41 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.41 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.41 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2244562 | 0.84 | MAPT (0.42) | ALDH1A1L3MBTL1CYP2D6MAPTSIRT6 | |
| SCHEMBL29119482 | 0.84 | MAPT (0.55) | ALDH1A1L3MBTL1MAPTSIRT6LMNA | |
| SCHEMBL29119403 | 0.82 | MAPT (0.39) | ALDH1A1L3MBTL1MAPTSIRT6LMNA | |
| SCHEMBL2061820 | 0.79 | ALDH1A1 (0.58) | ALDH1A1L3MBTL1CYP2D6MAPTSIRT6 | |
| SCHEMBL2247039 | 0.79 | MAPT (0.50) | ALDH1A1L3MBTL1MAPTSIRT6DRD2 | |
| SCHEMBL1669119 | 0.77 | MAPT (0.50) | ALDH1A1L3MBTL1MAPTSIRT6LMNA | |
| SCHEMBL2248302 | 0.77 | MAPT (0.50) | ALDH1A1L3MBTL1MAPTSIRT6LMNA | |
| SCHEMBL722818 | 0.76 | HPGD (0.44) | ALDH1A1L3MBTL1MAPTSIRT6LMNA | |
| SCHEMBL29119439 | 0.76 | DRD2 (0.43) | ALDH1A1L3MBTL1MAPTSIRT6DRD2 | |
| SCHEMBL29119480 | 0.75 | TP53 (0.55) | ALDH1A1L3MBTL1CYP2D6MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116888127-A | Tri-fused ring HPK1 inhibitor and application thereof | 轩竹生物科技股份有限公司 | 2023-10-13 | — | — | CN | disclosed |
| WO-2022188823-A1 | TRICYCLIC HPK1 INHIBITOR AND USE THEREOF | 山东轩竹医药科技有限公司 | 2022-09-15 | — | — | WO | disclosed |