Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 12/20 | 0.39 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2061774 | 0.82 | GAA (0.50) | MAPTSIRT6ALDH1A1MEN1KMT2A | |
| SCHEMBL29119488 | 0.82 | ALDH1A1 (0.44) | MAPTSIRT6ALDH1A1MEN1KMT2A | |
| SCHEMBL29119482 | 0.78 | MAPT (0.55) | MAPTSIRT6ALDH1A1MEN1KMT2A | |
| SCHEMBL29119509 | 0.78 | TP53 (0.42) | MAPTALDH1A1KMT2ALMNAKDM4E | |
| SCHEMBL2060527 | 0.77 | GAA (0.54) | MAPTMEN1KMT2ALMNAPOLB | |
| SCHEMBL29119474 | 0.77 | PNMT (0.43) | MAPTALDH1A1MEN1KMT2ACYP1A2 | |
| SCHEMBL2247039 | 0.73 | MAPT (0.50) | MAPTSIRT6ALDH1A1MEN1KMT2A | |
| SCHEMBL29860127 | 0.73 | ATAD2 (0.49) | MAPTALDH1A1KMT2ALMNAKDM4E | |
| SCHEMBL29119500 | 0.73 | ATAD2 (0.49) | MAPTALDH1A1KMT2ALMNAKDM4E | |
| SCHEMBL2244562 | 0.73 | MAPT (0.42) | MAPTSIRT6ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116888127-A | Tri-fused ring HPK1 inhibitor and application thereof | 轩竹生物科技股份有限公司 | 2023-10-13 | — | — | CN | disclosed |
| WO-2022188823-A1 | TRICYCLIC HPK1 INHIBITOR AND USE THEREOF | 山东轩竹医药科技有限公司 | 2022-09-15 | — | — | WO | disclosed |