Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | LAP3 | P28838 | 2/20 | 0.33 |
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.32 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.32 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.32 |
| ▸ | PGR | P06401 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | CACNA2D2 | Q9NY47 | 1/20 | 0.32 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.32 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29120919 | 1.00 | TSHR (0.37) | TSHRLMNACHRM2CHRM4CHRM5 | |
| SCHEMBL29120908 | 1.00 | TSHR (0.37) | TSHRLMNACHRM2CHRM4CHRM5 | |
| SCHEMBL29120907 | 0.75 | FOLH1 (0.35) | TSHRFOLH1 | |
| SCHEMBL29100176 | 0.75 | LMNA (0.39) | TSHRLMNACHRM2CHRM4CHRM5 | |
| SCHEMBL22501355 | 0.75 | LMNA (0.39) | TSHRLMNACHRM2CHRM4CHRM5 | |
| SCHEMBL22501356 | 0.75 | LMNA (0.39) | TSHRLMNACHRM2CHRM4CHRM5 | |
| SCHEMBL8155376 | 0.74 | TDP1 (0.42) | TSHRLMNACHRM2CHRM4CHRM5 | |
| SCHEMBL225530 | 0.71 | TSHR (0.58) | TSHRLMNACHRM2CHRM4CHRM5 | |
| SCHEMBL17943255 | 0.70 | SLC7A5 (0.54) | TSHRTDP1LAP3CACNA2D1CACNB3 | |
| SCHEMBL8088103 | 0.70 | SLC7A5 (0.54) | TSHRTDP1LAP3CACNA2D1CACNB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109641863-B | Intermediate for synthesizing carfilzomib and synthesis of pharmaceutically acceptable salt thereof | 美国安进公司 | 2023-10-20 | — | — | CN | disclosed |