Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.58 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.54 |
| ▸ | NAAA | Q02083 | 1/20 | 0.48 |
| ▸ | RAD52 | P43351 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.46 |
| ▸ | FAAH | O00519 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.43 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15610425 | 1.00 | TSHR (0.58) | TSHRHCAR2NAAARAD52NPSR1 | |
| SCHEMBL5052459 | 1.00 | TSHR (0.58) | TSHRHCAR2NAAARAD52NPSR1 | |
| SCHEMBL15610423 | 1.00 | TSHR (0.58) | TSHRHCAR2NAAARAD52NPSR1 | |
| SCHEMBL27725776 | 1.00 | TSHR (0.58) | TSHRHCAR2NAAARAD52NPSR1 | |
| SCHEMBL11741170 | 0.98 | TSHR (0.55) | TSHRHCAR2NAAARAD52NPSR1 | |
| SCHEMBL11749762 | 0.98 | TSHR (0.55) | TSHRHCAR2NAAARAD52NPSR1 | |
| SCHEMBL598745 | 0.93 | ALDH1A1 (0.52) | TSHRHCAR2NAAARAD52NPSR1 | |
| SCHEMBL598743 | 0.93 | ALDH1A1 (0.52) | TSHRHCAR2NAAARAD52NPSR1 | |
| SCHEMBL7767048 | 0.93 | ALDH1A1 (0.52) | TSHRHCAR2NAAARAD52NPSR1 | |
| SCHEMBL8383264 | 0.86 | TSHR (0.58) | TSHRHCAR2NAAARAD52NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240368065-A1 | CITRACONIC ACID AND DERIVATIVES THEREOF FOR USE AS A MEDICAMENT | Helmholtz-Zentrum für Infektionsforschung GmbH (DE) | 2024-11-07 | — | — | US | disclosed |
| EP-4326247-A1 | CITRACONIC ACID AND DERIVATIVES THEREOF FOR USE AS A MEDICAMENT | Helmholtz-Zentrum für Infektionsforschung GmbH (DE) | 2024-02-28 | — | — | EP | disclosed |
| CN-117202901-A | Use of citraconic acid and its derivatives as medicaments | 亥姆霍兹感染研究中心有限公司 | 2023-12-08 | — | — | CN | disclosed |
| WO-2022223778-A1 | CITRACONIC ACID AND DERIVATIVES THEREOF FOR USE AS A MEDICAMENT | Helmholtz-Zentrum für Infektionsforschung GmbH (DE) | 2022-10-27 | — | — | WO | disclosed |
| CN-112262189-B | Surface conditioner for water-based coating, water-based coating composition, coating film, and multilayer coating film | 楠本化成株式会社 | 2022-05-03 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240368065-A1 | CITRACONIC ACID AND DERIVATIVES THEREOF FOR USE AS A MEDICAMENT | HCAR2, ECI1, CYP27A1 | TSHR 4865/4885HCAR2 1/4885NAAA 1673/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.