Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Adipic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 5/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.52 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.50 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.48 |
| ▸ | PPARG | P37231 | 7/20 | 0.48 |
| ▸ | PPARD | Q03181 | 7/20 | 0.48 |
| ▸ | PPARA | Q07869 | 7/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | TLR2 | O60603 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | FABP4 | P15090 | 2/20 | 0.48 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.48 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ESR1 | P03372 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 3-Hydroxybutyric Acid, (+/-)- SCHEMBL28198123 | 0.98 | TSHR (0.57) | LMNATSHRNFKB1PMP22GPR84 | |
| 3-Hydroxybutyric Acid, (+/-)- SCHEMBL8443628 | 0.91 | GPR84 (0.60) | LMNATSHRNFKB1PMP22AKR1B1 | |
| Hexanoate SCHEMBL27663752 | 0.91 | AKR1B1 (0.67) | LMNATSHRAKR1B1GPR84PPARG | |
| Succinic Acid SCHEMBL29124668 | 0.90 | LMNA (0.50) | LMNAALDH1A1SLC22A6 | |
| Succinic Acid SCHEMBL7617176 | 0.90 | LMNA (0.50) | LMNAALDH1A1SLC22A6 | |
| 3-Hydroxybutyric Acid, (+/-)- SCHEMBL28671508 | 0.89 | GPR84 (0.58) | LMNATSHRNFKB1PMP22AKR1B1 | |
| Octanoic Acid SCHEMBL27951149 | 0.89 | GPR84 (0.68) | LMNATSHRAKR1B1GPR84PPARG | |
| 3-Hydroxybutyric Acid, (+/-)- SCHEMBL928794 | 0.89 | AKR1B1 (0.56) | TSHRAKR1B1GPR84PPARGPPARD | |
| 3-Hydroxybutyric Acid, (+/-)- SCHEMBL2034805 | 0.89 | CAMK2A (0.61) | LMNATSHRNFKB1PMP22AKR1B1 | |
| (R)-3-Hydroxybutanoate SCHEMBL6231727 | 0.89 | CAMK2A (0.61) | LMNATSHRNFKB1PMP22AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116917264-A | Process for preparing hydroxybutyric acid carboxylic ester | 凯托利皮克斯治疗有限责任公司 | 2023-10-20 | — | — | CN | disclosed |