Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.36 |
| ▸ | USP28 | Q96RU2 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2916517 | 0.91 | MEN1 (0.41) | CRBNNR1H4MAPTMAPK1ALDH1A1 | |
| SCHEMBL2910562 | 0.88 | HPGD (0.41) | CRBNMAPTRAB9AMAPK1ALDH1A1 | |
| SCHEMBL2915057 | 0.86 | CRBN (0.39) | CRBNMAPTRAB9AGAAMAPK1 | |
| SCHEMBL2907766 | 0.85 | KMT2A (0.41) | CRBNNR1H4MAPTRAB9AMAPK1 | |
| SCHEMBL1530899 | 0.83 | AURKB (0.41) | CRBNNR1H4MAPTRAB9AGAA | |
| SCHEMBL2913169 | 0.81 | CRBN (0.40) | CRBNNR1H4MAPTGAAMAPK1 | |
| SCHEMBL2914837 | 0.80 | KMT2A (0.41) | CRBNNR1H4MAPTRAB9AMAPK1 | |
| SCHEMBL2915689 | 0.80 | F10 (0.39) | CRBNMAPTRAB9AMAPK1ALDH1A1 | |
| SCHEMBL2913875 | 0.79 | F10 (0.37) | CRBNNR1H4MAPTRAB9AGAA | |
| SCHEMBL2910630 | 0.78 | MEN1 (0.46) | NR1H4MAPTRAB9AMAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2725015-A1 | Uracil or thymine derivative for treating hepatitis c | AbbVie Bahamas Ltd. (BS) | 2014-04-30 | — | — | EP | claimed |
| EP-2222646-A1 | URACIL OR THYMINE DERIVATIVE FOR TREATING HEPATITIS C | Abbott Laboratories (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2009039127-A1 | URACIL OR THYMINE DERIVATIVE FOR TREATING HEPATITIS C | ABBOTT LABORATORIES (US) | 2009-03-26 | — | — | WO | disclosed |