Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.41 |
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
| ▸ | GRM4 | Q14833 | 5/20 | 0.35 |
| ▸ | F10 | P00742 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2907766 | 0.92 | KMT2A (0.41) | KMT2AMEN1ALDH1A1MAPK1S1PR1 | |
| SCHEMBL2913166 | 0.87 | XDH (0.38) | KMT2AMEN1ALDH1A1MAPK1KDM4E | |
| SCHEMBL2916517 | 0.86 | MEN1 (0.41) | KMT2AMEN1ALDH1A1MAPK1KDM4E | |
| SCHEMBL2915057 | 0.85 | CRBN (0.39) | KMT2AMEN1ALDH1A1MAPK1KDM4E | |
| SCHEMBL1530674 | 0.82 | S1PR1 (0.41) | KMT2AMEN1ALDH1A1MAPK1S1PR1 | |
| SCHEMBL2915428 | 0.81 | RAB9A (0.40) | KMT2AMEN1ALDH1A1MAPK1KDM4E | |
| SCHEMBL2912681 | 0.80 | CRBN (0.38) | KMT2AMEN1ALDH1A1MAPK1NR1H4 | |
| SCHEMBL2910683 | 0.80 | ALDH1A1 (0.36) | ALDH1A1NR1H4F10RAB9AMAPT | |
| SCHEMBL2910291 | 0.80 | CNR2 (0.38) | KMT2AMEN1ALDH1A1KDM4EHTT | |
| SCHEMBL2915315 | 0.79 | KIF18A (0.35) | NR1H4F10POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222646-A1 | URACIL OR THYMINE DERIVATIVE FOR TREATING HEPATITIS C | Abbott Laboratories (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2009039127-A1 | URACIL OR THYMINE DERIVATIVE FOR TREATING HEPATITIS C | ABBOTT LABORATORIES (US) | 2009-03-26 | — | — | WO | disclosed |