Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 2/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2915428 | 0.89 | RAB9A (0.40) | HPGDMAPK10SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL2916517 | 0.89 | MEN1 (0.41) | CRBNMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL2912681 | 0.88 | CRBN (0.38) | HPGDSMN1; SMN2RAB9ANPC1CRBN | |
| SCHEMBL2908369 | 0.87 | MAPT (0.37) | HPGDSMN1; SMN2RAB9ANPC1NPSR1 | |
| SCHEMBL2910630 | 0.87 | MEN1 (0.46) | RAB9ANPC1MEN1KMT2AALDH1A1 | |
| SCHEMBL2915916 | 0.85 | CRBN (0.39) | HPGDSMN1; SMN2RAB9ANPC1NPSR1 | |
| SCHEMBL2915057 | 0.84 | CRBN (0.39) | SMN1; SMN2RAB9ANPC1CRBNMEN1 | |
| SCHEMBL2915218 | 0.84 | CYP3A4 (0.40) | CRBNADRB1CYP3A4 | |
| SCHEMBL3107879 | 0.84 | MAPT (0.52) | HPGDSMN1; SMN2RAB9ANPC1MEN1 | |
| SCHEMBL2907766 | 0.84 | KMT2A (0.41) | SMN1; SMN2RAB9ANPC1CRBNMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222646-A1 | URACIL OR THYMINE DERIVATIVE FOR TREATING HEPATITIS C | Abbott Laboratories (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2009039127-A1 | URACIL OR THYMINE DERIVATIVE FOR TREATING HEPATITIS C | ABBOTT LABORATORIES (US) | 2009-03-26 | — | — | WO | disclosed |