Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 4/20 | 0.37 |
| ▸ | GSK3A | P49840 | 3/20 | 0.37 |
| ▸ | CDK1 | P06493 | 2/20 | 0.33 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.33 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.33 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 2/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.32 |
| ▸ | MET | P08581 | 1/20 | 0.31 |
| ▸ | AXL | P30530 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.30 |
| ▸ | EIF4E | P06730 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2911576 | 0.92 | GSK3B (0.36) | GSK3BGSK3ACDK1CCNB2CCNB1 | |
| SCHEMBL2904015 | 0.92 | GSK3B (0.43) | GSK3BGSK3ACDK1CCNB2CCNB1 | |
| SCHEMBL2910224 | 0.92 | GSK3B (0.42) | GSK3BGSK3ACDK1CCNB2CCNB1 | |
| SCHEMBL2909502 | 0.92 | GSK3B (0.35) | GSK3BGSK3ACDK1CCNB2CCNB1 | |
| SCHEMBL2914083 | 0.90 | MET (0.35) | GSK3BGSK3ACDK1CCNB2CCNB1 | |
| SCHEMBL2912304 | 0.89 | GSK3B (0.38) | GSK3BGSK3ACDK1CCNB2CCNB1 | |
| SCHEMBL1219461 | 0.86 | GSK3B (0.49) | GSK3BGSK3ACDK1CCNB2CCNB1 | |
| SCHEMBL2910220 | 0.84 | GSK3B (0.39) | GSK3BGSK3ACDK1CCNB2CCNB1 | |
| SCHEMBL2909914 | 0.84 | GSK3B (0.43) | GSK3BGSK3ACDK1CCNB2CCNB1 | |
| SCHEMBL2906814 | 0.84 | ALOX5AP (0.36) | GSK3BGSK3ACDK1CCNB2CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537099-B1 | PYRROLE BASED INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | NOVARTIS VACCINES & DIAGNOSTIC (US) | 2010-08-11 | — | — | EP | disclosed |