Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 7/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.52 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 3/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2912817 | 0.92 | CSF1R (0.58) | CSF1RMAPTGAATHRBLMNA | |
| SCHEMBL2907950 | 0.92 | CSF1R (0.65) | CSF1RMAPTGAATHRBKCNH2 | |
| SCHEMBL2912356 | 0.91 | CSF1R (0.58) | CSF1RMAPTGAATHRBLMNA | |
| SCHEMBL2910481 | 0.90 | CSF1R (0.65) | CSF1RMAPTGAATHRBKCNH2 | |
| SCHEMBL23575731 | 0.85 | CA2 (0.60) | MAPTGAASMN1; SMN2TP53CA2 | |
| SCHEMBL2912285 | 0.85 | CSF1R (0.58) | CSF1RMAPTGAATHRBLMNA | |
| SCHEMBL2911495 | 0.85 | CA2 (0.58) | CSF1RMAPTGAATHRBKCNH2 | |
| SCHEMBL2911359 | 0.85 | CSF1R (0.59) | CSF1RMAPTGAATHRBSMN1; SMN2 | |
| SCHEMBL23575679 | 0.84 | MAPK1 (0.52) | MAPTGAATHRBLMNASMN1; SMN2 | |
| SCHEMBL2911260 | 0.84 | CSF1R (0.65) | CSF1RMAPTGAATHRBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010496-B1 | 4-ANILINOQUINOLINE-3-CARBOXAMIDES AS CSF-1R KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2010-08-25 | — | — | EP | disclosed |