Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | KMO | O15229 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | STAT3 | P40763 | 1/20 | 0.39 |
| ▸ | STAT1 | P42224 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28669409 | 0.83 | MAP4K4 (0.48) | MEN1KMT2AKMOKDM4ENPC1 | |
| SCHEMBL29623827 | 0.83 | MAP4K4 (0.48) | MEN1KMT2AKMOKDM4ENPC1 | |
| SCHEMBL3397244 | 0.81 | MAP4K4 (0.52) | MEN1KMT2AKMOKDM4EDYRK1A | |
| SCHEMBL14638214 | 0.79 | DYRK1A (0.60) | MEN1KMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1469470 | 0.76 | MAP4K4 (0.48) | MEN1KMT2AKMOKDM4EDYRK1A | |
| SCHEMBL823888 | 0.76 | KMO (0.58) | KMOKDM4ENPC1RAB9A | |
| SCHEMBL14637950 | 0.75 | GRM5 (0.49) | MEN1KMT2AKMODYRK1ACLK4 | |
| SCHEMBL3401551 | 0.74 | KMO (0.50) | MEN1KMT2AKMOCLK4MAPT | |
| SCHEMBL4326155 | 0.73 | KMT2A (0.54) | MEN1KMT2AKDM4ENPC1RAB9A | |
| SCHEMBL823885 | 0.73 | HSD17B1 (0.55) | KMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117088851-A | Pyrimidine amine NUAK inhibitor and preparation method and application thereof | 特科罗生物科技(成都)有限公司 | 2023-11-21 | — | — | CN | disclosed |