Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 2/20 | 0.48 |
| ▸ | KMO | O15229 | 2/20 | 0.44 |
| ▸ | KIF11 | P52732 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
| ▸ | IKBKB | O14920 | 1/20 | 0.37 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29623827 | 1.00 | MAP4K4 (0.48) | MAP4K4KMOKIF11MAPTL3MBTL1 | |
| SCHEMBL29131069 | 0.83 | MEN1 (0.50) | KMOMAPTMEN1KMT2ANPC1 | |
| SCHEMBL28744879 | 0.80 | PLAAT3 (0.45) | MAP4K4KIF11MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL29223622 | 0.79 | MAP4K4 (0.50) | MAP4K4KMOKIF11MEN1KMT2A | |
| SCHEMBL29131077 | 0.78 | MAP4K4 (0.45) | MAP4K4KMOMAPTL3MBTL1MEN1 | |
| SCHEMBL212750 | 0.76 | NPC1 (0.61) | MAPTL3MBTL1MEN1KMT2ANPC1 | |
| SCHEMBL29763706 | 0.75 | KCNH2 (0.49) | MAPTMEN1KMT2ANPC1RAB9A | |
| SCHEMBL15881243 | 0.75 | LMNA (0.35) | MAP4K4KMOL3MBTL1MEN1KMT2A | |
| SCHEMBL27913276 | 0.75 | CYP2D6 (0.53) | KIF11MAPTMEN1KMT2ANPC1 | |
| SCHEMBL29069789 | 0.75 | KIF11 (0.42) | KMOKIF11MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113583020-B | JAK2 inhibitor and application | 百极弘烨（广东）医药科技有限公司 | 2022-04-22 | — | — | CN | disclosed |
| CN-113583020-A | JAK2 inhibitor and application | 百极弘烨(南通)医药科技有限公司 | 2021-11-02 | — | — | CN | disclosed |