Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 5/20 | 0.70 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.54 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2628645 | 1.00 | TRPM8 (0.70) | TRPM8EPHX1TRPV1HPGDCYP2C9 | |
| SCHEMBL2628616 | 0.89 | TRPM8 (0.72) | TRPM8EPHX1TRPV1NPC1ALDH1A1 | |
| SCHEMBL4886771 | 0.89 | TRPM8 (0.72) | TRPM8EPHX1TRPV1HPGDNPC1 | |
| SCHEMBL369792 | 0.89 | TRPM8 (0.72) | TRPM8EPHX1TRPV1NPC1ALDH1A1 | |
| SCHEMBL13989013 | 0.86 | TRPM8 (0.76) | TRPM8EPHX1TRPV1HPGDNPC1 | |
| SCHEMBL299356 | 0.86 | TRPM8 (0.58) | TRPM8EPHX1TRPV1ALDH1A1MEN1 | |
| SCHEMBL2628779 | 0.86 | TRPM8 (0.58) | TRPM8EPHX1TRPV1ALDH1A1MEN1 | |
| SCHEMBL4817319 | 0.86 | TRPM8 (0.75) | TRPM8EPHX1TRPV1HPGDNPC1 | |
| SCHEMBL10073486 | 0.86 | TRPM8 (0.75) | TRPM8EPHX1TRPV1HPGDNPC1 | |
| SCHEMBL2628672 | 0.86 | TRPM8 (0.75) | TRPM8EPHX1TRPV1HPGDNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8664261-B2 | Organic compounds having cooling properties | GIVAUDAN S.A. (CH) | 2014-03-04 | — | — | US | claimed |
| US-8377422-B2 | Carboxamide derivatives having cooling properties | GIVAUDAN S.A. (CH) | 2013-02-19 | — | — | US | claimed |
| US-20120095042-A1 | Organic Compounds Having Cooling Properties | GIVAUDAN SA (CH) | 2012-04-19 | — | — | US | claimed |
| EP-2427170-A2 | ORGANIC COMPOUNDS HAVING COOLING PROPERTIES | Givaudan SA (CH) | 2012-03-14 | — | — | EP | claimed |
| US-20110182833-A1 | Carboxamide Derivatives Having Cooling Properties | GIVAUDAN SA (CH) | 2011-07-28 | — | — | US | claimed |
| US-20100297038-A1 | Benzimidazole Derivatives And Their Use As Cooling Agents | GIVAUDAN S.A. (CH) | 2010-11-25 | — | — | US | claimed |
| EP-2250154-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS COOLING AGENTS | Givaudan SA (CH) | 2010-11-17 | — | — | EP | claimed |
| WO-2010128026-A2 | ORGANIC COMPOUNDS | GIVAUDAN SA (CH) | 2010-11-11 | — | — | WO | claimed |
| EP-2229352-A2 | CARBOXAMIDE DERIVATIVES HAVING COOLING PROPERTIES | Givaudan SA (CH) | 2010-09-22 | — | — | EP | claimed |
| WO-2009089641-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS COOLING AGENTS | GIVAUDAN SA (CH) | 2009-07-23 | — | — | WO | claimed |
| WO-2009070910-A2 | CARBOXAMIDE DERIVATIEVES HAVING COOLING PROPERTIES | GIVAUDAN SA (CH) | 2009-06-11 | — | — | WO | claimed |
| EP-2296759-B1 | COOLING COMPOSITION | GIVAUDAN SA (CH) | 2019-10-02 | — | — | EP | disclosed |
| CN-102036716-B | Cooling composition | GIVAUDAN S.A. (CH) | 2016-02-10 | — | — | CN | disclosed |
| US-8664261-B2 | Organic compounds having cooling properties | GIVAUDAN S.A. (CH) | 2014-03-04 | — | — | US | disclosed |
| US-8377422-B2 | Carboxamide derivatives having cooling properties | GIVAUDAN S.A. (CH) | 2013-02-19 | — | — | US | disclosed |
| US-20100297038-A1 | Benzimidazole Derivatives And Their Use As Cooling Agents | GIVAUDAN S.A. (CH) | 2010-11-25 | — | — | US | disclosed |
| US-20100292294-A1 | Compositions Comprising a Physiological Coolant | GIVAUDAN NEDERLAND SERVICES B.V. (NL) | 2010-11-18 | — | — | US | disclosed |
| EP-2134319-A2 | COMPOSITIONS COMPRISING A PHYSIOLOGICAL COOLANT | Givaudan Nederland Services B.V. (NL) | 2009-12-23 | — | — | EP | disclosed |
| WO-2009140783-A1 | COOLING COMPOSITION | GIVAUDAN SA (CH) | 2009-11-26 | — | — | WO | disclosed |
| WO-2008107137-A2 | COMPOSITIONS COMPRISING A PHYSIOLOGICAL COOLANT | GIVAUDAN NEDERLAND SERVICES B.V. (NL) | 2008-09-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100297038-A1 | Benzimidazole Derivatives And Their Use As Cooling Agents | OR10J3, H1-3, ORC3 | TRPM8 2049/4885EPHX1 2518/4885TRPV1 1623/4885 |
| US-20110182833-A1 | Carboxamide Derivatives Having Cooling Properties | CPS1, NQO2, NDUFA2 | TRPM8 376/4885EPHX1 3112/4885TRPV1 161/4885 |
| US-20120095042-A1 | Organic Compounds Having Cooling Properties | ME3, ME2, MSMO1 | TRPM8 361/4885EPHX1 1320/4885TRPV1 945/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.