Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.46 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.39 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1073012 | 0.88 | USP30 (0.48) | GPR119USP30KITLRRK2 | |
| SCHEMBL29504310 | 0.88 | USP30 (0.48) | GPR119USP30KITLRRK2 | |
| SCHEMBL29132274 | 0.88 | GPR119 (0.48) | GPR119USP30FAAHHRH3 | |
| SCHEMBL31583702 | 0.87 | USP30 (0.53) | GPR119USP30CNR1HRH3 | |
| SCHEMBL29132112 | 0.83 | GPR119 (0.48) | GPR119USP30HRH3 | |
| SCHEMBL23860643 | 0.82 | USP30 (0.43) | GPR119USP30TBK1LRRK2 | |
| SCHEMBL30234588 | 0.82 | USP30 (0.43) | GPR119USP30TBK1LRRK2 | |
| SCHEMBL23875401 | 0.82 | USP30 (0.43) | GPR119USP30TBK1LRRK2 | |
| SCHEMBL29132280 | 0.82 | GPR119 (0.52) | GPR119CNR1FAAHHRH3LRRK2 | |
| SCHEMBL29132154 | 0.81 | GRIN2B (0.43) | FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4308557-A1 | INDAZOLE BASED COMPOUNDS AND ASSOCIATED METHODS OF USE | Arvinas Operations, Inc. (US) | 2024-01-24 | — | — | EP | disclosed |
| CN-117321046-A | Indazole-based compounds and related methods of use | 阿维纳斯企业公司 | 2023-12-29 | — | — | CN | disclosed |
| WO-2022198112-A1 | INDAZOLE BASED COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2022-09-22 | — | — | WO | disclosed |