Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR2 | P21452 | 2/20 | 0.49 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.46 |
| ▸ | CDK2 | P24941 | 5/20 | 0.46 |
| ▸ | CCNE2 | O96020 | 3/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.46 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | STK17A | Q9UEE5 | 5/20 | 0.39 |
| ▸ | STK17B | O94768 | 3/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.38 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3725653 | 0.90 | CDK2 (0.46) | TACR2CCNE1CDK2CCNE2CCNA2 | |
| SCHEMBL2910733 | 0.90 | CDK2 (0.52) | TACR2CCNE1CDK2CCNE2CCNA2 | |
| SCHEMBL3726417 | 0.88 | TACR2 (0.42) | TACR2CCNE1CDK2CCNE2CCNA2 | |
| SCHEMBL3714767 | 0.88 | CDK2 (0.43) | TACR2CCNE1CDK2CCNE2CCNA2 | |
| SCHEMBL3724487 | 0.86 | CDK2 (0.47) | TACR2CCNE1CDK2CCNE2CCNA2 | |
| SCHEMBL3719064 | 0.85 | CYP3A4 (0.43) | TACR2CCNE1CDK2CCNE2CCNA2 | |
| SCHEMBL3721963 | 0.83 | P2RX7 (0.41) | TACR2CCNE1CDK2CCNE2CCNA2 | |
| SCHEMBL2910995 | 0.83 | CDK2 (0.52) | CCNE1CDK2CCNE2CCNA2CCNA1 | |
| SCHEMBL3720174 | 0.82 | CDK2 (0.62) | TACR2CCNE1CDK2CCNE2CCNA2 | |
| SCHEMBL3724956 | 0.82 | CDK2 (0.42) | TACR2CCNE1CDK2CCNE2CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010139288-A1 | 5,7-DISUBSTITUTED 3-ISOPROPYLPYRAZOLO[4,3-D]PYRIMIDINES FOR USE AS MEDICAMENTS AND PHARMACEUTICAL COMPOSITIONS | C3 BIO GMBH (DE) | 2010-12-09 | — | — | WO | disclosed |