Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 6/20 | 0.44 |
| ▸ | JAK2 | O60674 | 6/20 | 0.39 |
| ▸ | JAK1 | P23458 | 2/20 | 0.39 |
| ▸ | PLK1 | P53350 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | WDR5 | P61964 | 1/20 | 0.35 |
| ▸ | INSR | P06213 | 1/20 | 0.35 |
| ▸ | AXL | P30530 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27238154 | 1.00 | JAK3 (0.44) | JAK3JAK2JAK1PLK1MAPT | |
| SCHEMBL29133287 | 0.86 | JAK3 (0.42) | JAK3JAK2JAK1PLK1MAPT | |
| SCHEMBL29133291 | 0.86 | JAK3 (0.40) | JAK3JAK2JAK1PLK1MAPT | |
| SCHEMBL4674001 | 0.84 | MAP4K4 (0.41) | JAK3JAK2JAK1MAP4K4ELANE | |
| SCHEMBL29133298 | 0.82 | WDR5 (0.43) | JAK3JAK2JAK1PLK1MAPT | |
| SCHEMBL27238331 | 0.82 | WDR5 (0.43) | JAK3JAK2JAK1PLK1MAPT | |
| SCHEMBL30018543 | 0.81 | PLK1 (0.41) | JAK3JAK2JAK1PLK1MAPT | |
| SCHEMBL29757770 | 0.80 | PLK1 (0.40) | PLK1MAPTMEN1ALDH1A1KMT2A | |
| SCHEMBL24251657 | 0.80 | ALDH1A1 (0.49) | MAPTMEN1ALDH1A1KMT2ATDP1 | |
| SCHEMBL25348538 | 0.78 | MAPT (0.50) | MAPTMEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115836064-A | Triazine derivative with EGFR (epidermal growth factor receptor) inhibitory activity and preparation method and application thereof | 上海和誉生物医药科技有限公司 | 2023-03-21 | — | — | CN | disclosed |