Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.49 |
| ▸ | MAPT | P10636 | 8/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25348538 | 0.90 | MAPT (0.50) | ALDH1A1MAPTHTTMEN1KMT2A | |
| SCHEMBL24251659 | 0.80 | ALDH1A1 (0.44) | ALDH1A1MAPTMAPK1POLBTDP1 | |
| SCHEMBL29133293 | 0.80 | JAK3 (0.44) | ALDH1A1MAPTTDP1MEN1KMT2A | |
| SCHEMBL27238154 | 0.80 | JAK3 (0.44) | ALDH1A1MAPTTDP1MEN1KMT2A | |
| SCHEMBL4679150 | 0.79 | CASP3 (0.41) | ALDH1A1MAPTMAPK1POLBTDP1 | |
| SCHEMBL24251673 | 0.78 | ALDH1A1 (0.44) | ALDH1A1MAPTMAPK1POLBTDP1 | |
| SCHEMBL31289142 | 0.77 | MERTK (0.41) | ALDH1A1MAPTMAPK1TDP1HTT | |
| SCHEMBL27238177 | 0.76 | MAPT (0.35) | MAPTHTTMEN1KMT2ACYP1A2 | |
| SCHEMBL27238236 | 0.76 | MAPT (0.35) | MAPTHTTMEN1KMT2ACYP1A2 | |
| SCHEMBL28358932 | 0.75 | MAPT (0.46) | ALDH1A1MAPTHTTLMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022033455-A1 | TRIAZINE DERIVATIVE HAVING EGFR INHIBITORY ACTIVITY, PREPARATION METHOD THEREFOR AND USE THEREOF | 上海和誉生物医药科技有限公司 | 2022-02-17 | — | — | WO | disclosed |