Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN5A | Q14524 | 9/20 | 0.52 |
| ▸ | CSF1R | P07333 | 9/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 9/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | HTR1D | P28221 | 1/20 | 0.42 |
| ▸ | HTR1B | P28222 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2911894 | 0.90 | SCN5A (0.65) | SCN5ACSF1RKCNH2 | |
| SCHEMBL2909682 | 0.85 | CSF1R (0.64) | SCN5ACSF1RKCNH2 | |
| SCHEMBL2909211 | 0.83 | CSF1R (0.51) | SCN5ACSF1RKCNH2 | |
| SCHEMBL2913426 | 0.81 | CSF1R (0.51) | SCN5ACSF1RKCNH2 | |
| SCHEMBL2911555 | 0.81 | KCNH2 (0.53) | SCN5ACSF1RKCNH2 | |
| SCHEMBL2912641 | 0.79 | CSF1R (0.60) | SCN5ACSF1RKCNH2HTR1AHTR1D | |
| SCHEMBL2914061 | 0.79 | CSF1R (0.49) | SCN5ACSF1RKCNH2HTR1AHTR1D | |
| SCHEMBL2913359 | 0.78 | CSF1R (0.66) | SCN5ACSF1RKCNH2 | |
| SCHEMBL2908767 | 0.77 | CSF1R (0.83) | SCN5ACSF1RKCNH2 | |
| SCHEMBL2911700 | 0.76 | KCNH2 (0.51) | SCN5ACSF1RKCNH2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010496-B1 | 4-ANILINOQUINOLINE-3-CARBOXAMIDES AS CSF-1R KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2010-08-25 | — | — | EP | disclosed |