Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 7/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.44 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.42 |
| ▸ | CDK4 | P11802 | 1/20 | 0.42 |
| ▸ | CCND1 | P24385 | 1/20 | 0.42 |
| ▸ | CDK9 | P50750 | 1/20 | 0.42 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.42 |
| ▸ | CDK11A | Q9UQ88 | 1/20 | 0.42 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.42 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.41 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.41 |
| ▸ | WEE1 | P30291 | 1/20 | 0.41 |
| ▸ | EML4 | Q9HC35 | 2/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | HTR1D | P28221 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2911203 | 0.90 | CSF1R (0.56) | CSF1RKCNH2SCN5AEPHA2EPHB4 | |
| SCHEMBL2905929 | 0.88 | CSF1R (0.53) | CSF1RKCNH2SCN5ACCNT1CDK4 | |
| SCHEMBL2909682 | 0.83 | CSF1R (0.64) | CSF1RKCNH2SCN5A | |
| SCHEMBL4433976 | 0.80 | CSF1R (0.48) | CSF1REPHA2EPHB4ERBB2KDR | |
| SCHEMBL2907522 | 0.80 | CSF1R (0.48) | CSF1RKCNH2SCN5AERBB2 | |
| SCHEMBL2911700 | 0.80 | KCNH2 (0.51) | CSF1RKCNH2SCN5AKDRHTR1A | |
| SCHEMBL2913360 | 0.79 | SCN5A (0.52) | CSF1RKCNH2SCN5AHTR1AHTR1D | |
| SCHEMBL2908706 | 0.79 | KCNH2 (0.46) | CSF1RKCNH2SCN5AEML4ALK | |
| SCHEMBL2912636 | 0.79 | CSF1R (0.75) | CSF1RKCNH2SCN5APAK1BRD4 | |
| SCHEMBL2911370 | 0.79 | CSF1R (0.94) | CSF1RKCNH2SCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010496-B1 | 4-ANILINOQUINOLINE-3-CARBOXAMIDES AS CSF-1R KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2010-08-25 | — | — | EP | disclosed |