Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 0.51 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | CSF1R | P07333 | 7/20 | 0.44 |
| ▸ | EGFR | P00533 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | FBP1 | P09467 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | STK4 | Q13043 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2911203 | 0.90 | CSF1R (0.56) | KCNH2SCN5AMAPTCSF1REGFR | |
| SCHEMBL2908706 | 0.87 | KCNH2 (0.46) | KCNH2SCN5AMAPTCSF1REGFR | |
| SCHEMBL2907522 | 0.86 | CSF1R (0.48) | KCNH2SCN5AMAPTCSF1REGFR | |
| SCHEMBL2911555 | 0.84 | KCNH2 (0.53) | KCNH2SCN5AMAPTCSF1RTP53 | |
| SCHEMBL2908143 | 0.81 | KCNH2 (0.77) | KCNH2SCN5ACSF1REGFR | |
| SCHEMBL2905929 | 0.80 | CSF1R (0.53) | KCNH2SCN5ACSF1RKDR | |
| SCHEMBL2909682 | 0.80 | CSF1R (0.64) | KCNH2SCN5ACSF1R | |
| SCHEMBL2911696 | 0.80 | KCNH2 (0.64) | KCNH2SCN5AMAPTL3MBTL1CSF1R | |
| SCHEMBL2912641 | 0.80 | CSF1R (0.60) | KCNH2SCN5ACSF1RHTR1AHTR7 | |
| SCHEMBL2912772 | 0.79 | MAPT (0.46) | KCNH2SCN5AMAPTCSF1REGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010496-B1 | 4-ANILINOQUINOLINE-3-CARBOXAMIDES AS CSF-1R KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2010-08-25 | — | — | EP | disclosed |