Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 7/20 | 0.57 |
| ▸ | EGFR | P00533 | 4/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | APP | P05067 | 2/20 | 0.57 |
| ▸ | CCNC | P24863 | 1/20 | 0.56 |
| ▸ | CDKN1A | P38936 | 1/20 | 0.56 |
| ▸ | CDK8 | P49336 | 1/20 | 0.56 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.56 |
| ▸ | CNR1 | P21554 | 1/20 | 0.53 |
| ▸ | CNR2 | P34972 | 1/20 | 0.53 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.52 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.52 |
| ▸ | FYN | P06241 | 1/20 | 0.50 |
| ▸ | SRC | P12931 | 1/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.48 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29133792 | 0.78 | PDPK1 (0.42) | EGFRCCNCCDKN1ACDK8CDK19 | |
| SCHEMBL24576519 | 0.77 | GALR3 (0.58) | EGFRLMNADYRK1ANR2F2 | |
| SCHEMBL29775101 | 0.77 | GALR3 (0.58) | EGFRLMNADYRK1ANR2F2 | |
| SCHEMBL24576525 | 0.77 | GALR3 (0.58) | EGFRLMNADYRK1ANR2F2 | |
| SCHEMBL24609450 | 0.77 | LMNA (0.56) | EGFRLMNADYRK1ANR2F2 | |
| SCHEMBL13283269 | 0.76 | HTT (0.76) | HTTEGFRMAPK1LMNAAPP | |
| SCHEMBL4741967 | 0.75 | HTT (0.70) | HTTEGFRMAPK1LMNAAPP | |
| SCHEMBL9921509 | 0.75 | PIK3CD (0.85) | HTTEGFRMAPK1LMNAAPP | |
| SCHEMBL13912334 | 0.75 | EGFR (0.76) | HTTEGFRMAPK1LMNAAPP | |
| SCHEMBL13192080 | 0.75 | HTT (0.70) | HTTEGFRMAPK1LMNAAPP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117295716-A | Substituted aminobenzyl heteroaryl compounds as EGFR and/or PI3K inhibitors | 麦克尼斯迪克治疗有限公司 | 2023-12-26 | — | — | CN | disclosed |