Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17494851 | 0.85 | NR4A2 (0.46) | NR4A2CA2HSD17B10POLBL3MBTL1 | |
| SCHEMBL28440107 | 0.82 | ABL1 (0.56) | NR4A2CA2HSD17B10POLBL3MBTL1 | |
| SCHEMBL21505100 | 0.80 | HSD17B10 (0.65) | CA2HSD17B10POLBL3MBTL1ALDH1A1 | |
| SCHEMBL20505240 | 0.80 | NR4A2 (0.45) | NR4A2CA2HSD17B10POLBL3MBTL1 | |
| SCHEMBL17504939 | 0.80 | NR4A2 (0.49) | NR4A2CA2HSD17B10POLBL3MBTL1 | |
| SCHEMBL29295506 | 0.79 | L3MBTL1 (0.52) | NR4A2CA2HSD17B10POLBL3MBTL1 | |
| SCHEMBL29134333 | 0.79 | IDO1 (0.40) | NR4A2L3MBTL1ALDH1A1 | |
| SCHEMBL24946536 | 0.77 | NR4A2 (0.42) | NR4A2HSD17B10POLBL3MBTL1ALDH1A1 | |
| SCHEMBL4585841 | 0.76 | NR4A2 (0.46) | NR4A2CA2HSD17B10POLBL3MBTL1 | |
| SCHEMBL20505053 | 0.74 | ALDH1A1 (0.47) | HSD17B10POLBL3MBTL1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4313967-A1 | KHK INHIBITORS | GILEAD SCIENCES, INC. (US) | 2024-02-07 | — | — | EP | disclosed |
| CN-117120429-A | KHK inhibitor | 吉利德科学公司 | 2023-11-24 | — | — | CN | disclosed |
| WO-2022212194-A1 | KHK INHIBITORS | GILEAD SCIENCES, INC. (US) | 2022-10-06 | — | — | WO | disclosed |