Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.39 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30656595 | 1.00 | MAPK8 (0.46) | MAPK8KMT2AMRGPRX4CYP2D6CYP2C9 | |
| SCHEMBL29778984 | 0.87 | BRD4 (0.47) | MAPK8KMT2AMEN1SMN1; SMN2HPGD | |
| SCHEMBL29778993 | 0.87 | MAPK8 (0.59) | MAPK8HIF1AIDO1ALDH1A1 | |
| SCHEMBL29136046 | 0.87 | BRD4 (0.47) | MAPK8KMT2AMEN1SMN1; SMN2HPGD | |
| SCHEMBL29136019 | 0.79 | KMT2A (0.45) | MAPK8KMT2AMRGPRX4CYP2D6CYP2C9 | |
| SCHEMBL30656512 | 0.79 | KMT2A (0.45) | MAPK8KMT2AMRGPRX4CYP2D6CYP2C9 | |
| SCHEMBL30656549 | 0.77 | IDO1 (0.51) | MRGPRX4IDO1SMN1; SMN2 | |
| SCHEMBL29136018 | 0.77 | IDO1 (0.51) | MRGPRX4IDO1SMN1; SMN2 | |
| SCHEMBL2419642 | 0.77 | LMNA (0.52) | MAPK8KMT2AHTTMEN1SMN1; SMN2 | |
| SCHEMBL2420795 | 0.71 | ALDH1A1 (0.48) | MAPK8KMT2AIDO1ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117136186-A | Selective inhibitors of ROCK1 and ROCK2 protein kinases and uses thereof | 盖诺斯克公司 | 2023-11-28 | — | — | CN | disclosed |