Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.38 |
| ▸ | NEK2 | P51955 | 2/20 | 0.34 |
| ▸ | PKMYT1 | Q99640 | 2/20 | 0.33 |
| ▸ | ATR | Q13535 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | GABRP | O00591 | 1/20 | 0.33 |
| ▸ | GABRD | O14764 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.33 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10547988 | 0.75 | KDM4E (0.46) | KDM4EKMT2ACYP3A4GABRPGABRD | |
| SCHEMBL27573639 | 0.75 | CSNK1D (0.45) | KDM4ESMN1; SMN2NPC1ALDH1A1GAA | |
| SCHEMBL28149481 | 0.73 | KMT2A (0.43) | KDM4EKMT2AGPR35GABRPGABRD | |
| SCHEMBL3300495 | 0.73 | KDM4E (0.43) | KDM4EKMT2AGPR35ATRGABRP | |
| Bromide SCHEMBL11550756 | 0.71 | KDM4E (0.42) | KDM4EKMT2AGPR35ATRGABRP | |
| Hydrochloric Acid SCHEMBL11547616 | 0.71 | KMT2A (0.42) | KDM4EKMT2AGPR35GABRPGABRD | |
| SCHEMBL21994300 | 0.70 | GABRP (0.42) | KDM4EKMT2ANEK2GABRPGABRD | |
| SCHEMBL27542494 | 0.69 | TDO2 (0.44) | ATR | |
| SCHEMBL16445970 | 0.68 | KDM4E (0.46) | KDM4EKMT2ANEK2CYP3A4GABRP | |
| SCHEMBL31233636 | 0.67 | HCAR3 (0.40) | GPR35POLBKDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117355521-A | Heteroaryl inhibitors of plasma kallikrein | 武田药品工业株式会社 | 2024-01-05 | — | — | CN | disclosed |