Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | KLKB1 | P03952 | 3/20 | 0.31 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | DRD4 | P21917 | 1/20 | 0.30 |
| ▸ | DRD3 | P35462 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29137027 | 0.83 | KLKB1 (0.33) | GRM5KLKB1 | |
| SCHEMBL29137030 | 0.83 | GRM5 (0.32) | GRM5KLKB1 | |
| SCHEMBL29137007 | 0.81 | KDM4E (0.39) | EPHX2ALDH1A1RXFP1KLKB1METTL3 | |
| SCHEMBL24737489 | 0.80 | PIK3R1 (0.33) | EPHX2KLKB1DRD2DRD4DRD3 | |
| SCHEMBL21368003 | 0.80 | DRD2 (0.32) | DRD2DRD4DRD3 | |
| SCHEMBL24739338 | 0.80 | KDM4E (0.38) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL27029949 | 0.79 | KLKB1 (0.39) | EPHX2ALDH1A1MAPK1KLKB1METTL3 | |
| SCHEMBL24739861 | 0.79 | DRD2 (0.32) | DRD2DRD4DRD3 | |
| SCHEMBL24738153 | 0.78 | RXFP1 (0.37) | EPHX2RXFP1 | |
| SCHEMBL31658609 | 0.78 | DRD2 (0.34) | DRD2DRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117355523-A | Polycyclic inhibitors of plasma kallikrein | 武田药品工业株式会社 | 2024-01-05 | — | — | CN | disclosed |
| CN-117355521-A | Heteroaryl inhibitors of plasma kallikrein | 武田药品工业株式会社 | 2024-01-05 | — | — | CN | disclosed |