Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | KLKB1 | P03952 | 3/20 | 0.33 |
| ▸ | THRA | P10827 | 2/20 | 0.33 |
| ▸ | THRB | P10828 | 2/20 | 0.33 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.32 |
| ▸ | PPARA | Q07869 | 1/20 | 0.30 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.30 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27029949 | 0.85 | KLKB1 (0.39) | KDM4EALDH1A1EPHX2KLKB1METTL3 | |
| SCHEMBL24737489 | 0.83 | PIK3R1 (0.33) | EPHX2KLKB1 | |
| SCHEMBL24739338 | 0.83 | KDM4E (0.38) | KDM4EALDH1A1POLBTDP1THRB | |
| SCHEMBL24739861 | 0.82 | DRD2 (0.32) | — | |
| SCHEMBL29136933 | 0.81 | GRM5 (0.31) | ALDH1A1EPHX2KLKB1METTL3RXFP1 | |
| SCHEMBL31658609 | 0.81 | DRD2 (0.34) | — | |
| SCHEMBL21355494 | 0.81 | DRD2 (0.32) | KLKB1 | |
| SCHEMBL21368003 | 0.81 | DRD2 (0.32) | — | |
| SCHEMBL24737556 | 0.80 | RXFP1 (0.50) | KDM4EALDH1A1TDP1L3MBTL1EPHX2 | |
| SCHEMBL24740076 | 0.79 | HCAR3 (0.34) | EPHX2KLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117355521-A | Heteroaryl inhibitors of plasma kallikrein | 武田药品工业株式会社 | 2024-01-05 | — | — | CN | disclosed |