Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | CA9 | Q16790 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29302376 | 1.00 | MAPT (0.49) | MAPTPKMTSHRALDH1A1CA12 | |
| SCHEMBL29879866 | 1.00 | MAPT (0.49) | MAPTPKMTSHRALDH1A1CA12 | |
| SCHEMBL29137011 | 1.00 | MAPT (0.49) | MAPTPKMTSHRALDH1A1CA12 | |
| SCHEMBL6081536 | 0.87 | MAPT (0.47) | MAPTPKMTSHRALDH1A1CA12 | |
| SCHEMBL25456800 | 0.86 | KIF11 (0.49) | MAPTPKMTSHR | |
| SCHEMBL4773039 | 0.86 | KIF11 (0.49) | MAPTPKMTSHR | |
| SCHEMBL4140870 | 0.84 | ALDH1A1 (0.47) | MAPTPKMALDH1A1TDP1 | |
| SCHEMBL31320831 | 0.84 | TSHR (0.48) | MAPTPKMTSHRALDH1A1CA12 | |
| SCHEMBL21091367 | 0.84 | SLC9A1 (0.54) | MAPTPKMSLC9A1 | |
| SCHEMBL4134712 | 0.84 | TSHR (0.48) | MAPTPKMTSHRALDH1A1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117355521-A | Heteroaryl inhibitors of plasma kallikrein | 武田药品工业株式会社 | 2024-01-05 | — | — | CN | disclosed |