SCHEMBL29137929

SCHEMBL29137929

CC(C)(C)[Si](C)(C)OCc1cc(F)c(C=O)c2cc(OC(N)=O)ncc12

nearest known ligand 0.32

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
BACE1 P56817 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29137930 0.80 BACE1 (0.31) BACE1
SCHEMBL29875163 0.78 BACE1 (0.33) BACE1
SCHEMBL26933001 0.76 BACE1 (0.32) BACE1
SCHEMBL29890015 0.76 BACE1 (0.34) BACE1
SCHEMBL26933626 0.76 BACE1 (0.34) BACE1
SCHEMBL29274170 0.69 BACE1 (0.33) BACE1
SCHEMBL29137974 0.69 ERN1 (0.34)
SCHEMBL24439598 0.68 BACE1 (0.33) BACE1
SCHEMBL2596518 0.67 BACE1 (0.45) BACE1
SCHEMBL29274171 0.67 BACE1 (0.33) BACE1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117062804-A 1, 3-substituted cyclobutyl derivatives and their use 诺华股份有限公司 2023-11-14 CN disclosed