SCHEMBL29137930

SCHEMBL29137930

CC(C)(C)[Si](C)(C)OCc1cc(F)cc2cc(OC(N)=O)ncc12

nearest known ligand 0.31

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
BACE1 P56817 1/20 0.31
TACR1 P25103 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29137929 0.80 BACE1 (0.32) BACE1
SCHEMBL29137941 0.80 GRM5 (0.33)
SCHEMBL29874531 0.76 PDPK1 (0.34) BACE1TACR1
SCHEMBL29274170 0.75 BACE1 (0.33) BACE1
SCHEMBL26933447 0.74 HDAC1 (0.32) BACE1TACR1
SCHEMBL26933288 0.71 MAOA (0.38) BACE1TACR1
SCHEMBL30636354 0.71 MAOA (0.38) BACE1TACR1
SCHEMBL29274171 0.71 BACE1 (0.33) BACE1
SCHEMBL29137957 0.71 ERN1 (0.36)
SCHEMBL29137986 0.70

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117062804-A 1, 3-substituted cyclobutyl derivatives and their use 诺华股份有限公司 2023-11-14 CN disclosed