Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 5/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | CHRNB4 | P30926 | 4/20 | 0.30 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.30 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.30 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2720888 | 0.92 | GAA (0.38) | MAPTGAAKDM4EPKMKMT2A | |
| SCHEMBL2916034 | 0.89 | MAPT (0.36) | MAPTGAAKDM4EPKMKMT2A | |
| SCHEMBL2061505 | 0.81 | GAA (0.39) | MAPTGAAKDM4EPKMKMT2A | |
| SCHEMBL2915985 | 0.79 | ALDH1A1 (0.41) | MAPTGAAKMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL6369246 | 0.79 | MAPT (0.37) | MAPTGAAKDM4EPKMKMT2A | |
| SCHEMBL30173345 | 0.77 | MAPT (0.38) | MAPTGAAKDM4EPKMKMT2A | |
| SCHEMBL6376509 | 0.76 | KMT2A (0.60) | MAPTGAAKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL8566982 | 0.76 | NOS3 (0.47) | MAPTGAAKDM4EALDH1A1CHRNB4 | |
| SCHEMBL6373833 | 0.76 | KMT2A (0.58) | MAPTGAAKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL6376953 | 0.75 | KMT2A (0.51) | MAPTGAAKDM4EKMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222647-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | Cephalon, Inc. (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2008051547-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | CEPHALON, INC. (US) | 2008-05-02 | — | — | WO | disclosed |