Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 4/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2724189 | 0.92 | ALDH1A1 (0.43) | ALDH1A1LMNAMAPTGAACHRNB4 | |
| SCHEMBL2060680 | 0.85 | CHRNB4 (0.40) | ALDH1A1LMNAMAPTGAACHRNB4 | |
| SCHEMBL2913833 | 0.79 | MAPT (0.36) | ALDH1A1MAPTGAACHRNB4CHRNA3 | |
| SCHEMBL2061015 | 0.79 | CHRNB4 (0.46) | ALDH1A1LMNAMAPTGAACHRNB4 | |
| SCHEMBL5051534 | 0.77 | GAA (0.42) | ALDH1A1LMNAMAPTGAASMN1; SMN2 | |
| SCHEMBL25607650 | 0.77 | PIK3CD (0.43) | ALDH1A1MAPTSMN1; SMN2MEN1CRHBP | |
| SCHEMBL6368485 | 0.76 | SMN1; SMN2 (0.43) | ALDH1A1LMNAMAPTSMN1; SMN2KMT2A | |
| SCHEMBL12404774 | 0.75 | ALDH1A1 (0.35) | ALDH1A1LMNAMAPTGAACHRNB4 | |
| SCHEMBL2910729 | 0.75 | ESPL1 (0.38) | ALDH1A1LMNAMAPTGAA | |
| SCHEMBL2061320 | 0.74 | ALDH1A1 (0.43) | ALDH1A1LMNAMAPTGAACHRNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222647-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | Cephalon, Inc. (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2008051547-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | CEPHALON, INC. (US) | 2008-05-02 | — | — | WO | disclosed |