Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.44 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | BCL2 | P10415 | 1/20 | 0.38 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | SSTR1 | P30872 | 4/20 | 0.36 |
| ▸ | SSTR3 | P32745 | 4/20 | 0.36 |
| ▸ | DRD2 | P14416 | 3/20 | 0.36 |
| ▸ | DRD4 | P21917 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29139938 | 1.00 | SIGMAR1 (0.44) | SIGMAR1TMEM97NAMPTBCL2BCL2L1 | |
| SCHEMBL29855777 | 1.00 | SIGMAR1 (0.44) | SIGMAR1TMEM97NAMPTBCL2BCL2L1 | |
| SCHEMBL28532862 | 0.83 | MAPT (0.41) | CYP2D6ALDH1A1CYP1A2CYP3A4GAA | |
| SCHEMBL29855898 | 0.82 | MAPT (0.36) | SIGMAR1TMEM97BCL2BCL2L1CYP2D6 | |
| SCHEMBL28522991 | 0.82 | RBP4 (0.41) | CYP2D6ALDH1A1CYP1A2CYP3A4GAA | |
| SCHEMBL28527478 | 0.80 | GPR119 (0.47) | NAMPTMAPT | |
| SCHEMBL28528284 | 0.79 | CYP2D6 (0.38) | CYP2D6CYP2C9CYP2C19HRH3 | |
| SCHEMBL28528279 | 0.79 | CYP2D6 (0.38) | CYP2D6CYP2C9CYP2C19HRH3 | |
| SCHEMBL28909558 | 0.78 | HRH3 (0.41) | CYP2D6MAPTCYP2C9CYP2C19HRH3 | |
| SCHEMBL28909552 | 0.78 | HRH3 (0.41) | CYP2D6MAPTCYP2C9CYP2C19HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117683029-A | Bcl-2 inhibitors | 百济神州有限公司 | 2024-03-12 | — | — | CN | disclosed |
| CN-117430601-A | Bcl-2 inhibitors | 百济神州有限公司 | 2024-01-23 | — | — | CN | disclosed |
| CN-112437772-B | Bcl-2 inhibitors | 百济神州有限公司 | 2023-11-21 | — | — | CN | disclosed |