Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | TYMS | P04818 | 1/20 | 0.39 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.38 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.38 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.38 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.38 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.37 |
| ▸ | CD44 | P16070 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | PRKCI | P41743 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2907226 | 0.92 | PBRM1 (0.41) | PBRM1CASP1CASP7HSD17B10BRD4 | |
| SCHEMBL17546199 | 0.89 | MAOA (0.44) | BRD4GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL1273997 | 0.83 | PBRM1 (0.47) | PBRM1CASP1CASP7HSD17B10BRD4 | |
| SCHEMBL31591225 | 0.83 | PBRM1 (0.47) | PBRM1CASP1CASP7HSD17B10TYMS | |
| SCHEMBL1512735 | 0.83 | PBRM1 (0.47) | PBRM1CASP1CASP7HSD17B10TYMS | |
| SCHEMBL10102257 | 0.76 | PBRM1 (0.50) | PBRM1CASP1CASP7HSD17B10BRD4 | |
| SCHEMBL4818430 | 0.76 | PBRM1 (0.41) | PBRM1CASP1CASP7HSD17B10BRD4 | |
| SCHEMBL14430312 | 0.76 | HSD17B1 (0.44) | PBRM1CASP1CASP7HSD17B10PTGS2 | |
| SCHEMBL11980463 | 0.76 | PBRM1 (0.41) | PBRM1CASP1CASP7HSD17B10BRD4 | |
| SCHEMBL19887446 | 0.76 | PBRM1 (0.41) | PBRM1CASP1CASP7HSD17B10TYMS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130017149-A1 | PHARMACEUTICAL COMPOUNDS | NEUROSCIENZE PHARMANESS S.C. A.R.L. (IT) | 2013-01-17 | — | — | US | disclosed |
| EP-2223914-A1 | Tricyclic condensed pyrazole derivatives as CB1 inhibitors | Neuroscienze Pharmaness S.C. A R.L. (IT) | 2010-09-01 | — | — | EP | disclosed |
| EP-2223913-A1 | Tricyclic pyrazole derivatives and microemulsions thereof as CB1- and/or CB2-inhibitors | Neuroscienze Pharmaness S.C. A R.L. (IT) | 2010-09-01 | — | — | EP | disclosed |
| US-20100215741-A1 | PHARMACEUTICAL COMPOUNDS | NEUROSCIENZE PHARMANESS S.C. A.R.L. (IT) | 2010-08-26 | — | — | US | disclosed |
| US-20100216785-A1 | PHARMACEUTICAL COMPOSITIONS | NEUROSCIENZE PHARMANESS S.C. A.R.L. (IT) | 2010-08-26 | — | — | US | disclosed |
| US-20090163559-A1 | Estrogen receptor modulators | MERCK SHARP & DOHME LLC | 2009-06-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100215741-A1 | PHARMACEUTICAL COMPOUNDS | CNR1, CNR2, TRPV1 | PBRM1 746/4885CASP1 2843/4885CASP7 3311/4885 |
| US-20130017149-A1 | PHARMACEUTICAL COMPOUNDS | CNR1, CNR2, TRPV1 | PBRM1 746/4885CASP1 2843/4885CASP7 3311/4885 |
| US-20090163559-A1 | Estrogen receptor modulators | GPER1, ESR2, ESRRA | PBRM1 2866/4885CASP1 3997/4885CASP7 4246/4885 |
| US-20100216785-A1 | PHARMACEUTICAL COMPOSITIONS | CNR2, CNR1, SGMS2 | PBRM1 2754/4885CASP1 3474/4885CASP7 2235/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.