SCHEMBL2915592

CNC(=O)c1ccccc1Nc1nc(Nc2ccc3c(c2)C2CCC3CN(CCOC)C2)ncc1Cl.CNC(=O)c1ccccc1Nc1nc(Nc2ccc3c(c2)C2CCC3CNC2)ncc1Cl

nearest known ligand 0.67

Predicted protein targets (top 9)

	gene	UniProt	supporting neighbours	confidence
▸	MET	P08581	15/20	0.67

▸	INSR	P06213	3/20	0.67

▸	ALK	Q9UM73	11/20	0.59

▸	EGFR	P00533	2/20	0.56

▸	MAPK8	P45983	1/20	0.54

▸	MAPK9	P45984	1/20	0.54

▸	MAPK10	P53779	1/20	0.54

▸	ULK1	O75385	1/20	0.53

▸	PTK2	Q05397	1/20	0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL884691	0.96	MET (0.71)	METINSRALKEGFRMAPK8
SCHEMBL884870	0.92	MET (0.71)	METINSRALKEGFRMAPK8
SCHEMBL2060554	0.90	MET (0.70)	METINSRALKEGFRMAPK8
SCHEMBL885245	0.88	MET (0.63)	METINSRALKEGFRMAPK8
SCHEMBL884620	0.87	MET (0.64)	METINSRALKEGFRMAPK8
SCHEMBL2914656	0.86	MET (0.59)	METINSRALKEGFRMAPK8
SCHEMBL3000085	0.86	MET (0.62)	METINSRALKEGFRMAPK8
SCHEMBL884818	0.85	MET (0.60)	METINSRALKEGFRMAPK8
SCHEMBL2909096	0.85	MET (0.60)	METINSRALKEGFRMAPK8
SCHEMBL884883	0.85	MET (0.60)	METINSRALKEGFRMAPK8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-2222647-A1	FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS	Cephalon, Inc. (US)	2010-09-01	—	—	EP	disclosed
WO-2008051547-A1	FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS	CEPHALON, INC. (US)	2008-05-02	—	—	WO	disclosed