Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.41 |
| ▸ | THRB | P10828 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | CASP1 | P29466 | 2/20 | 0.41 |
| ▸ | CA3 | P07451 | 1/20 | 0.41 |
| ▸ | CA6 | P23280 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.39 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 4/20 | 0.39 |
| ▸ | NT5E | P21589 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL10433540 | 0.85 | MAPT (0.61) | MAPTMEN1KMT2ARAB9ACYP3A4 | |
| Bicarbonate SCHEMBL11010145 | 0.85 | MAPT (0.61) | MAPTMEN1KMT2ARAB9ACYP3A4 | |
| Propionic Acid SCHEMBL27716552 | 0.84 | CYP19A1 (0.45) | MAPTRAB9ACYP3A4ALDH1A1HIF1A | |
| Phosphoric Acid SCHEMBL27960194 | 0.81 | FDPS (0.43) | MAPTMEN1KMT2ARAB9ACYP3A4 | |
| Formic Acid SCHEMBL28171969 | 0.81 | MAPT (0.42) | MAPTMEN1KMT2ARAB9ACYP3A4 | |
| Phosphoric Acid SCHEMBL28488468 | 0.79 | FDPS (0.42) | MAPTMEN1KMT2ARAB9ACYP3A4 | |
| Phenol SCHEMBL27896712 | 0.77 | CYP3A4 (0.55) | MAPTMEN1KMT2ARAB9ACYP3A4 | |
| Oxalic Acid SCHEMBL6915099 | 0.76 | MAPT (0.57) | MAPTMEN1KMT2ARAB9ACYP3A4 | |
| 4-Aminophenol SCHEMBL27835004 | 0.74 | ALDH1A1 (0.77) | MAPTMEN1KMT2ARAB9ACYP3A4 | |
| Aniline SCHEMBL8413315 | 0.73 | TSHR (0.73) | MAPTMEN1KMT2ARAB9ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117440813-A | EGFR degrading agents for treating brain or CNS cancer metastasis | C4医药公司 | 2024-01-23 | — | — | CN | disclosed |