SCHEMBL2914780

SCHEMBL2914780

COc1c(C#Cc2cc(F)c(NS(C)(=O)=O)cc2C)cc(N2C(=O)CCNC2=O)cc1C(C)(C)C

nearest known ligand 0.32

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
CRBN Q96SW2 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2910760 0.88 CRBN (0.33) CRBN
SCHEMBL2913397 0.85 CRBN (0.33) CRBN
SCHEMBL2916365 0.85 CRBN (0.40) CRBN
SCHEMBL2913987 0.84 CRBN (0.40) CRBN
SCHEMBL2912660 0.84 CRBN (0.32) CRBN
SCHEMBL2913638 0.82 HTR6 (0.35) CRBN
SCHEMBL1530613 0.82 CRBN (0.32) CRBN
SCHEMBL2915572 0.81 CRBN (0.40) CRBN
SCHEMBL2915214 0.81 CRBN (0.33) CRBN
SCHEMBL2915280 0.81 CRBN (0.34) CRBN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2222646-A1 URACIL OR THYMINE DERIVATIVE FOR TREATING HEPATITIS C Abbott Laboratories (US) 2010-09-01 EP disclosed
WO-2009039127-A1 URACIL OR THYMINE DERIVATIVE FOR TREATING HEPATITIS C ABBOTT LABORATORIES (US) 2009-03-26 WO disclosed