Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | CCNC | P24863 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.35 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9097301 | 0.99 | P2RX7 (0.41) | P2RX7HTR6CCNCCDK8CXCR2 | |
| Hydrochloric Acid SCHEMBL28357122 | 0.97 | P2RX7 (0.40) | P2RX7HTR6CCNCCDK8CXCR2 | |
| Bromide SCHEMBL28711468 | 0.90 | SIGMAR1 (0.37) | CYP19A1KDM4EMAPTCYP11B1CYP11B2 | |
| SCHEMBL27827661 | 0.88 | SIGMAR1 (0.38) | CYP19A1KDM4EMAPTCYP11B1CYP11B2 | |
| Hydrochloric Acid SCHEMBL27500541 | 0.86 | SIGMAR1 (0.37) | CYP19A1KDM4ECYP11B1CYP11B2 | |
| SCHEMBL31220239 | 0.84 | CCNE1 (0.38) | P2RX7HTR6CCNCCDK8CXCR2 | |
| SCHEMBL31220302 | 0.84 | SRPK1 (0.36) | P2RX7HTR6CCNCCDK8CXCR2 | |
| SCHEMBL31220218 | 0.83 | CCNE1 (0.38) | P2RX7HTR6CCNCCDK8CXCR2 | |
| SCHEMBL17431889 | 0.82 | KIF11 (0.42) | KDM4EPOLBCYP3A4MAPTLSS | |
| Hydrochloric Acid SCHEMBL32691838 | 0.82 | RHEB (0.42) | CCNCCDK8KDM4EPOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115505118-B | Preparation method and application of quick-response ionized polyphenyl ether electrochromic compound film | 浙江大学 | 2024-02-09 | — | — | CN | disclosed |
| CN-115505118-A | Preparation method and application of quick-response ionized polyphenyl ether electrochromic compound film | 浙江大学 | 2022-12-23 | — | — | CN | disclosed |