Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | MGAM | O43451 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | SI | P14410 | 1/20 | 0.30 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.30 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.30 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.30 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.30 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.30 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29153129 | 1.00 | TSHR (0.37) | TSHRPOLBBRD4KDM4ESMN1; SMN2 | |
| SCHEMBL21876568 | 0.83 | HSD11B1 (0.38) | TSHRPOLBKDM4ESMN1; SMN2MGAM | |
| SCHEMBL29170225 | 0.83 | SMN1; SMN2 (0.40) | TSHRPOLBBRD4SMN1; SMN2 | |
| SCHEMBL4257940 | 0.83 | HSD11B1 (0.38) | TSHRPOLBKDM4ESMN1; SMN2MGAM | |
| SCHEMBL29170224 | 0.83 | SMN1; SMN2 (0.40) | TSHRPOLBBRD4SMN1; SMN2 | |
| SCHEMBL14818161 | 0.81 | TSHR (0.39) | TSHRPOLBBRD4KDM4ESMN1; SMN2 | |
| SCHEMBL22128751 | 0.81 | NR1H2 (0.36) | KDM4ESMN1; SMN2 | |
| SCHEMBL30390162 | 0.81 | NR1H2 (0.40) | KDM4ESMN1; SMN2 | |
| SCHEMBL335294 | 0.79 | NR1H2 (0.47) | TSHRSMN1; SMN2 | |
| SCHEMBL10220897 | 0.79 | NR1H2 (0.47) | TSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117561249-A | Cereblon binding compounds, compositions thereof, and methods for their use in therapy | 细胞基因公司 | 2024-02-13 | — | — | CN | disclosed |
| CN-117545752-A | Cereblon binding compounds, compositions thereof, and methods for their use in therapy | 细胞基因公司 | 2024-02-09 | — | — | CN | disclosed |