Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 2/20 | 0.38 |
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
| ▸ | MGAM | O43451 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SI | P14410 | 1/20 | 0.36 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.34 |
| ▸ | PIN4 | Q9Y237 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21876568 | 1.00 | HSD11B1 (0.38) | HSD11B1GSK3AGSK3BMGAMGAA | |
| SCHEMBL29153128 | 0.83 | TSHR (0.37) | MGAMGAASIMGAM2KDM4E | |
| SCHEMBL29153129 | 0.83 | TSHR (0.37) | MGAMGAASIMGAM2KDM4E | |
| SCHEMBL2663490 | 0.83 | GSK3A (0.40) | HSD11B1GSK3AGSK3BMGAMGAA | |
| SCHEMBL13744392 | 0.80 | NR1H2 (0.44) | HSD11B1ALDH1A1ELANEKDM4ETSHR | |
| SCHEMBL3828337 | 0.80 | CHRM1 (0.40) | HSD11B1GSK3AGSK3BALDH1A1ELANE | |
| SCHEMBL3832320 | 0.80 | CHRM1 (0.40) | HSD11B1GSK3AGSK3BALDH1A1ELANE | |
| SCHEMBL22128751 | 0.79 | NR1H2 (0.36) | ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL4085410 | 0.77 | ALDH1A1 (0.43) | HSD11B1GSK3AGSK3BMGAMGAA | |
| SCHEMBL4085412 | 0.77 | ALDH1A1 (0.43) | HSD11B1GSK3AGSK3BMGAMGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7569563-B2 | Substituted quinolones II | AICURIS GMBH & CO. HK (DE) | 2009-08-04 | — | — | US | disclosed |
| US-20080261964-A1 | Substituted quinolones II | AICURIS GMBH & CO. KG (DE) | 2008-10-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080261964-A1 | Substituted quinolones II | TOP2A, TPMT, TOP2B | HSD11B1 2692/4885GSK3A 1934/4885GSK3B 1947/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.