Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 1.00 |
| ▸ | MAPT | P10636 | 3/20 | 1.00 |
| ▸ | RAB9A | P51151 | 3/20 | 1.00 |
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | HTT | P42858 | 3/20 | 1.00 |
| ▸ | NFKB1 | P19838 | 1/20 | 1.00 |
| ▸ | NFKB2 | Q00653 | 1/20 | 1.00 |
| ▸ | RELA | Q04206 | 1/20 | 1.00 |
| ▸ | CASP3 | P42574 | 2/20 | 0.74 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.74 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.74 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.69 |
| ▸ | SIRT1 | Q96EB6 | 6/20 | 0.68 |
| ▸ | MAOA | P21397 | 1/20 | 0.57 |
| ▸ | MAOB | P27338 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL289145 | 0.85 | SIRT1 (0.81) | NPC1MAPTRAB9ALMNAHTT | |
| SCHEMBL27861098 | 0.84 | SIRT1 (0.84) | NPC1MAPTRAB9ALMNAHTT | |
| SCHEMBL289081 | 0.82 | NPC1 (1.00) | NPC1MAPTRAB9ALMNAHTT | |
| SCHEMBL289885 | 0.77 | SIRT1 (0.74) | NPC1MAPTRAB9ALMNAHTT | |
| SCHEMBL29630236 | 0.76 | SIRT1 (0.66) | NPC1MAPTRAB9ALMNAHTT | |
| SCHEMBL3377499 | 0.76 | SIRT1 (0.66) | NPC1MAPTRAB9ALMNAHTT | |
| SCHEMBL9594944 | 0.75 | NPC1 (0.60) | NPC1MAPTRAB9ALMNAHTT | |
| SCHEMBL2916788 | 0.75 | MAOB (0.68) | NPC1MAPTRAB9ALMNAHTT | |
| SCHEMBL289568 | 0.74 | SIRT1 (0.70) | NPC1MAPTRAB9ALMNAHTT | |
| SCHEMBL31335179 | 0.73 | SIRT1 (0.63) | NPC1MAPTRAB9ALMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110065715-A1 | Nogo Receptor Binding Small Molecules to Promote Axonal Growth | YALE UNIVERSITY (US) | 2011-03-17 | — | — | US | claimed |
| EP-2220499-A2 | NOGO RECEPTOR BINDING SMALL MOLECULES TO PROMOTE AXONAL GROWTH | Yale University (US) | 2010-08-25 | — | — | EP | claimed |
| WO-2009073141-A2 | NOGO RECEPTOR BINDING SMALL MOLECULES TO PROMOTE AXONAL GROWTH | STRITTMATTER STEPHEN M (US) | 2009-06-11 | — | — | WO | claimed |
| US-20110065715-A1 | Nogo Receptor Binding Small Molecules to Promote Axonal Growth | YALE UNIVERSITY (US) | 2011-03-17 | — | — | US | disclosed |
| US-20110065715-A1 | Nogo Receptor Binding Small Molecules to Promote Axonal Growth | YALE UNIVERSITY (US) | 2011-03-17 | — | — | US | disclosed |
| US-20110065715-A1 | Nogo Receptor Binding Small Molecules to Promote Axonal Growth | YALE UNIVERSITY (US) | 2011-03-17 | — | — | US | disclosed |
| EP-2220499-A2 | NOGO RECEPTOR BINDING SMALL MOLECULES TO PROMOTE AXONAL GROWTH | Yale University (US) | 2010-08-25 | — | — | EP | disclosed |
| WO-2009073141-A2 | NOGO RECEPTOR BINDING SMALL MOLECULES TO PROMOTE AXONAL GROWTH | STRITTMATTER STEPHEN M (US) | 2009-06-11 | — | — | WO | disclosed |
| WO-2009073141-A2 | NOGO RECEPTOR BINDING SMALL MOLECULES TO PROMOTE AXONAL GROWTH | STRITTMATTER STEPHEN M (US) | 2009-06-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110065715-A1 | Nogo Receptor Binding Small Molecules to Promote Axonal Growth | NGFR, GAP43, BDNF | NPC1 706/4885MAPT 333/4885RAB9A 1015/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.