Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 5/20 | 0.81 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.74 |
| ▸ | NPC1 | O15118 | 4/20 | 0.74 |
| ▸ | RAB9A | P51151 | 3/20 | 0.74 |
| ▸ | MAPT | P10636 | 2/20 | 0.74 |
| ▸ | CASP3 | P42574 | 2/20 | 0.74 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.74 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.74 |
| ▸ | LMNA | P02545 | 2/20 | 0.74 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.74 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.74 |
| ▸ | HTT | P42858 | 1/20 | 0.74 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.74 |
| ▸ | RELA | Q04206 | 1/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.68 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.66 |
| ▸ | HPGD | P15428 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27861098 | 0.87 | SIRT1 (0.84) | SIRT1KMT2ANPC1RAB9AMAPT | |
| SCHEMBL2915316 | 0.85 | NPC1 (1.00) | SIRT1KMT2ANPC1RAB9AMAPT | |
| SCHEMBL3377499 | 0.82 | SIRT1 (0.66) | SIRT1KMT2ANPC1RAB9AMAPT | |
| SCHEMBL6345667 | 0.82 | KMT2A (0.61) | SIRT1KMT2ANPC1RAB9AMAPT | |
| SCHEMBL29630236 | 0.82 | SIRT1 (0.66) | SIRT1KMT2ANPC1RAB9AMAPT | |
| SCHEMBL289081 | 0.81 | NPC1 (1.00) | SIRT1KMT2ANPC1RAB9AMAPT | |
| SCHEMBL9594944 | 0.81 | NPC1 (0.60) | SIRT1KMT2ANPC1RAB9AMAPT | |
| SCHEMBL16541098 | 0.80 | RAB9A (1.00) | SIRT1KMT2ANPC1RAB9AMAPT | |
| SCHEMBL31335179 | 0.79 | SIRT1 (0.63) | SIRT1KMT2ANPC1RAB9AMAPT | |
| SCHEMBL20251011 | 0.77 | KMT2A (0.61) | SIRT1KMT2ANPC1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2959898-A1 | 4,5-DIOXO-NAPHTHO[1,2-b]FURANS AS SELECTIVE PEPTIDE DEFORMYLASE INHIBITORS | Sloan-Kettering Institute for Cancer Research (US) | 2015-12-30 | — | — | EP | disclosed |
| EP-2959898-A1 | 4,5-DIOXO-NAPHTHO[1,2-b]FURANS AS SELECTIVE PEPTIDE DEFORMYLASE INHIBITORS | Sloan-Kettering Institute for Cancer Research (US) | 2015-12-30 | — | — | EP | disclosed |
| EP-2427057-B1 | BENZOFURAN-4,5-DIONES AS SELECTIVE PEPTIDE DEFORMYLASE INHIBITORS | SLOAN KETTERING INST CANCER (US) | 2015-08-12 | — | — | EP | disclosed |
| EP-2427057-B1 | BENZOFURAN-4,5-DIONES AS SELECTIVE PEPTIDE DEFORMYLASE INHIBITORS | SLOAN KETTERING INST CANCER (US) | 2015-08-12 | — | — | EP | disclosed |
| CN-102603825-B | 5-thioxylopyranose derivatives | FOURNIER LAB SA | 2014-03-12 | — | — | CN | disclosed |
| US-8614237-B2 | Benzofuran-4,5-diones as selective peptide deformylase inhibitors | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2013-12-24 | — | — | US | disclosed |
| CN-101490073-B | Derivatives of 5-thioxylopyranose | FOURNIER LAB S A | 2012-12-05 | — | — | CN | disclosed |
| CN-102603825-A | New 5-thioxylopyranose derivatives | FOURNIER LAB SA | 2012-07-25 | — | — | CN | disclosed |
| US-20120071523-A1 | BENZOFURAN-4,5-DIONES AS SELECTIVE PEPTIDE DEFORMYLASE INHIBITORS | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2012-03-22 | — | — | US | disclosed |
| US-20120071523-A1 | BENZOFURAN-4,5-DIONES AS SELECTIVE PEPTIDE DEFORMYLASE INHIBITORS | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2012-03-22 | — | — | US | disclosed |
| US-20120071523-A1 | BENZOFURAN-4,5-DIONES AS SELECTIVE PEPTIDE DEFORMYLASE INHIBITORS | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2012-03-22 | — | — | US | disclosed |
| EP-2427057-A1 | BENZOFURAN-4,5-DIONES AS SELECTIVE PEPTIDE DEFORMYLASE INHIBITORS | Sloan-Kettering Institute for Cancer Research (US) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010129049-A1 | BENZOFURAN-4,5-DIONES AS SELECTIVE PEPTIDE DEFORMYLASE INHIBITORS | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2010-11-11 | — | — | WO | disclosed |
| WO-2010129049-A1 | BENZOFURAN-4,5-DIONES AS SELECTIVE PEPTIDE DEFORMYLASE INHIBITORS | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2010-11-11 | — | — | WO | disclosed |
| US-7652032-B2 | 5-Thioxylopyranose compounds | LABORATOIRES FOURNIER S.A. (FR) | 2010-01-26 | — | — | US | disclosed |
| EP-2041153-B1 | NEW 5-THIOXYLOPYRANOSE DERIVATIVES | FOURNIER LAB SA (FR) | 2009-10-21 | — | — | EP | disclosed |
| CN-101490073-A | Novel derivatives of 5-thioxylopyranose | FOURNIER LAB S A (FR) | 2009-07-22 | — | — | CN | disclosed |
| US-20090118325-A1 | 5-Thioxylopyranose Compounds | LABORATOIRES FOURNIER S.A. (FR) | 2009-05-07 | — | — | US | disclosed |
| EP-2041153-A1 | NEW 5-THIOXYLOPYRANOSE DERIVATIVES | Laboratoires Fournier S.A. (FR) | 2009-04-01 | — | — | EP | disclosed |
| WO-2008007027-A1 | NEW 5-THIOXYLOPYRANOSE DERIVATIVES | LABORATOIRES FOURNIER S.A. (FR) | 2008-01-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090118325-A1 | 5-Thioxylopyranose Compounds | STS, F2, CBR1 | SIRT1 1480/4885KMT2A 4035/4885NPC1 3742/4885 |
| US-20120071523-A1 | BENZOFURAN-4,5-DIONES AS SELECTIVE PEPTIDE DEFORMYLASE INHIBITORS | PDF, EIF5B, EIF4E | SIRT1 1438/4885KMT2A 3066/4885NPC1 1866/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.