Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 | P21728 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.32 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.32 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.32 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.32 |
| ▸ | INSR | P06213 | 1/20 | 0.32 |
| ▸ | FES | P07332 | 1/20 | 0.32 |
| ▸ | FER | P16591 | 1/20 | 0.32 |
| ▸ | FLT4 | P35916 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2479144 | 1.00 | DRD1 (0.35) | DRD1BRD4DRD2HTR2AHRH3 | |
| SCHEMBL3007732 | 0.84 | IDO1 (0.41) | DRD1OPRL1 | |
| SCHEMBL2908344 | 0.82 | GAA (0.38) | DRD1DRD2HTR2AHRH3GAA | |
| SCHEMBL2908455 | 0.79 | DRD2 (0.36) | DRD1BRD4DRD2HTR2ASLC6A4 | |
| SCHEMBL520119 | 0.77 | HRH3 (0.44) | BRD4HRH3GAAMAPTSMN1; SMN2 | |
| SCHEMBL24740620 | 0.76 | GAA (0.43) | BRD4DRD2HTR2AHRH3GAA | |
| SCHEMBL2912290 | 0.76 | CNR1 (0.38) | DRD1BRD4DRD2HTR2AHRH3 | |
| SCHEMBL17729306 | 0.75 | IDO1 (0.42) | DRD1DRD2HTR2ASLC6A4 | |
| SCHEMBL521174 | 0.70 | CNR1 (0.48) | DRD1BRD4GAAMAPTSMN1; SMN2 | |
| SCHEMBL2917635 | 0.69 | HRH3 (0.49) | DRD1DRD2HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222647-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | Cephalon, Inc. (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2008051547-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | CEPHALON, INC. (US) | 2008-05-02 | — | — | WO | disclosed |