Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.49 |
| ▸ | DRD2 | P14416 | 4/20 | 0.49 |
| ▸ | DRD3 | P35462 | 4/20 | 0.49 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.48 |
| ▸ | DRD1 | P21728 | 4/20 | 0.48 |
| ▸ | DRD5 | P21918 | 4/20 | 0.48 |
| ▸ | DRD4 | P21917 | 2/20 | 0.47 |
| ▸ | HTR2C | P28335 | 3/20 | 0.46 |
| ▸ | HTR2B | P41595 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2915791 | 0.80 | AXL (0.45) | HRH3IRAK4 | |
| SCHEMBL520119 | 0.78 | HRH3 (0.44) | HRH3IRAK4 | |
| SCHEMBL2916757 | 0.76 | MTNR1B (0.43) | — | |
| SCHEMBL2061466 | 0.76 | ALK (0.41) | IRAK4HTR2CHTR2B | |
| SCHEMBL9729875 | 0.74 | IRAK4 (0.48) | HRH3IRAK4 | |
| Hydrochloric Acid SCHEMBL9341173 | 0.74 | HTR2C (0.55) | HRH3DRD2DRD3DRD1DRD5 | |
| SCHEMBL2061719 | 0.73 | ALK (0.42) | HRH3IRAK4 | |
| SCHEMBL2061586 | 0.73 | ADRA1A (0.38) | DRD2DRD3HTR2CHTR2B | |
| SCHEMBL521323 | 0.73 | ALK (0.42) | HRH3IRAK4 | |
| SCHEMBL2370682 | 0.72 | HRH3 (0.53) | HRH3DRD2DRD3DRD1DRD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222647-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | Cephalon, Inc. (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2008051547-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | CEPHALON, INC. (US) | 2008-05-02 | — | — | WO | disclosed |