Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.33 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.31 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.31 |
| ▸ | AKT1 | P31749 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26983725 | 0.95 | JMJD6 (0.30) | JMJD6RPS6KB1AKT1 | |
| SCHEMBL30119774 | 0.82 | DYRK1A (0.30) | — | |
| SCHEMBL26983719 | 0.78 | PIM1 (0.33) | — | |
| SCHEMBL30050566 | 0.78 | PIM1 (0.33) | — | |
| SCHEMBL30119819 | 0.76 | RET (0.33) | RPS6KB1AKT1 | |
| SCHEMBL30780318 | 0.73 | TYK2 (0.43) | — | |
| SCHEMBL26983744 | 0.73 | TYK2 (0.43) | — | |
| SCHEMBL30780336 | 0.72 | TYK2 (0.36) | — | |
| SCHEMBL30780279 | 0.72 | PARP1 (0.31) | — | |
| SCHEMBL30780359 | 0.71 | TYK2 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117362343-A | Compounds having selective TYK2/JAK1 inhibiting activity, pharmaceutical compositions containing the same and uses thereof | 爱科诺生物医药(香港)有限公司 | 2024-01-09 | — | — | CN | disclosed |