Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALM1 | P0DP23 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 2/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.36 |
| ▸ | TACR2 | P21452 | 2/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SHBG | P04278 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.36 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2912160 | 0.91 | SIGMAR1 (0.38) | SIGMAR1 | |
| SCHEMBL14884947 | 0.88 | TDP1 (0.38) | SIGMAR1LMNASCN9A | |
| 5-Methyl-3-Phenethyl-5-Phenyl-4,5-Dihydroisoxazole (Enantiomeric Mix) SCHEMBL2921112 | 0.82 | ITGB1 (0.38) | SIGMAR1SCN9A | |
| SCHEMBL5039479 | 0.78 | CA2 (0.35) | ESR1 | |
| SCHEMBL1238323 | 0.68 | ESR1 (0.62) | CALM1SIGMAR1ESR1ADRA2AADORA3 | |
| SCHEMBL2740913 | 0.66 | KDM4E (0.43) | SLC6A2SLC6A3KDM4ESCN9A | |
| SCHEMBL14168752 | 0.65 | ITGB1 (0.40) | ALDH1A1 | |
| SCHEMBL12595265 | 0.65 | BACE1 (0.39) | SCN9A | |
| SCHEMBL157572 | 0.65 | DPP4 (0.63) | ESR1ADRA2AADORA3TACR2SLC6A2 | |
| SCHEMBL1171041 | 0.64 | ESR1 (0.77) | CALM1SIGMAR1ESR1ADRA2AADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100267784-A1 | NOVEL 4,5-DIHYDROISOXAZOLES WITH ESTROGENIC ACTIVITY | PULKKINEN JUHA | 2010-10-21 | — | — | US | claimed |
| US-9278942-B2 | Non-steroidal compounds as androgen receptor modulators | FLX DISCOVERIES OY (FI) | 2016-03-08 | — | — | US | disclosed |
| US-9278942-B2 | Non-steroidal compounds as androgen receptor modulators | FLX DISCOVERIES OY (FI) | 2016-03-08 | — | — | US | disclosed |
| US-9278942-B2 | Non-steroidal compounds as androgen receptor modulators | FLX DISCOVERIES OY (FI) | 2016-03-08 | — | — | US | disclosed |
| US-20140275186-A1 | NOVEL NON-STEROIDAL COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS | FLX DISCOVERIES OY (FI) | 2014-09-18 | — | — | US | disclosed |
| US-20140275186-A1 | NOVEL NON-STEROIDAL COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS | FLX DISCOVERIES OY (FI) | 2014-09-18 | — | — | US | disclosed |
| US-20140275186-A1 | NOVEL NON-STEROIDAL COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS | FLX DISCOVERIES OY (FI) | 2014-09-18 | — | — | US | disclosed |
| EP-2768814-A1 | NOVEL NON-STEROIDAL COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS | FLX Discoveries OY (FI) | 2014-08-27 | — | — | EP | disclosed |
| WO-2013057372-A1 | NOVEL NON-STEROIDAL COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS | PULKKINEN JUHA (FI) | 2013-04-25 | — | — | WO | disclosed |
| US-20100267784-A1 | NOVEL 4,5-DIHYDROISOXAZOLES WITH ESTROGENIC ACTIVITY | PULKKINEN JUHA | 2010-10-21 | — | — | US | disclosed |
| US-20100267784-A1 | NOVEL 4,5-DIHYDROISOXAZOLES WITH ESTROGENIC ACTIVITY | PULKKINEN JUHA | 2010-10-21 | — | — | US | disclosed |
| US-20100267784-A1 | NOVEL 4,5-DIHYDROISOXAZOLES WITH ESTROGENIC ACTIVITY | PULKKINEN JUHA | 2010-10-21 | — | — | US | disclosed |
| EP-2222653-A1 | NOVEL 4,5-DIHYDROISOXAZOLES WITH ESTROGENIC ACTIVITY | Pulkkinen, Juha (FI) | 2010-09-01 | — | — | EP | disclosed |
| WO-2009066009-A1 | NOVEL 4,5-DIHYDROISOXAZOLES WITH ESTROGENIC ACTIVITY | PULKKINEN JUHA (FI) | 2009-05-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100267784-A1 | NOVEL 4,5-DIHYDROISOXAZOLES WITH ESTROGENIC ACTIVITY | ESR2, GPER1, CYP19A1 | CALM1 1441/4885SIGMAR1 884/4885ESR1 4/4885 |
| US-20140275186-A1 | NOVEL NON-STEROIDAL COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS | AR, NR5A1, SHBG | CALM1 3258/4885SIGMAR1 264/4885ESR1 46/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.