Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.34 |
| ▸ | KIF18A | Q8NI77 | 14/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | BCL2 | P10415 | 1/20 | 0.32 |
| ▸ | SCARB1 | Q8WTV0 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2913787 | 0.92 | KIF18A (0.39) | NR1H4KIF18AMAPTHSD17B10TSHR | |
| SCHEMBL2909532 | 0.89 | NR1H4 (0.39) | NR1H4KIF18AMAPTHSD17B10TSHR | |
| SCHEMBL2915115 | 0.86 | BCL2 (0.37) | NR1H4MAPTHSD17B10TSHRBCL2 | |
| SCHEMBL2913182 | 0.86 | NR1H4 (0.36) | NR1H4KIF18AMAPTHSD17B10TSHR | |
| SCHEMBL2915249 | 0.84 | ITGA4 (0.39) | MAPTHSD17B10TSHRSCARB1KDM4E | |
| SCHEMBL1530341 | 0.84 | AURKB (0.40) | NR1H4KIF18AMAPTHSD17B10TSHR | |
| SCHEMBL2907824 | 0.82 | MAPT (0.39) | NR1H4KIF18AMAPTHSD17B10TSHR | |
| SCHEMBL2907495 | 0.82 | NR1H4 (0.36) | NR1H4MAPTHSD17B10TSHRBCL2 | |
| SCHEMBL2915481 | 0.82 | NR1H4 (0.41) | NR1H4MAPTHSD17B10TSHRBCL2 | |
| SCHEMBL2913600 | 0.82 | NR1H4 (0.40) | NR1H4MAPTHSD17B10TSHRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222646-A1 | URACIL OR THYMINE DERIVATIVE FOR TREATING HEPATITIS C | Abbott Laboratories (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2009039127-A1 | URACIL OR THYMINE DERIVATIVE FOR TREATING HEPATITIS C | ABBOTT LABORATORIES (US) | 2009-03-26 | — | — | WO | disclosed |